chore: data model changes (#117)

See: https://github.com/dnpm-dip/mtb-model/commit/3234082af1faf40d6b2faa67f8afcef95d2a5a3b

3 files changed, 1022 insertions, 999 deletions

diff --git a/src/main/kotlin/dev/dnpm/etl/processor/pseudonym/extensions.kt b/src/main/kotlin/dev/dnpm/etl/processor/pseudonym/extensions.kt
index 7ce1e0c..8d5a2cc 100644
--- a/src/main/kotlin/dev/dnpm/etl/processor/pseudonym/extensions.kt
+++ b/src/main/kotlin/dev/dnpm/etl/processor/pseudonym/extensions.kt
@@ -255,6 +255,7 @@ infix fun Mtb.pseudonymizeWith(pseudonymizeService: PseudonymizeService) {
     this.claims?.forEach { it.patient.id = patientPseudonym }
     this.claimResponses?.forEach { it.patient.id = patientPseudonym }
     this.diagnoses?.forEach { it.patient.id = patientPseudonym }
+    this.familyMemberHistories?.forEach { it.patient.id = patientPseudonym }
     this.histologyReports?.forEach {
         it.patient.id = patientPseudonym
         it.results.tumorMorphology?.patient?.id = patientPseudonym
diff --git a/src/test/kotlin/dev/dnpm/etl/processor/pseudonym/ExtensionsTest.kt b/src/test/kotlin/dev/dnpm/etl/processor/pseudonym/ExtensionsTest.kt
index e30ee73..65986f1 100644
--- a/src/test/kotlin/dev/dnpm/etl/processor/pseudonym/ExtensionsTest.kt
+++ b/src/test/kotlin/dev/dnpm/etl/processor/pseudonym/ExtensionsTest.kt
@@ -207,7 +207,7 @@ class ExtensionsTest {
     inner class UsingDnpmV2Datamodel {
 
         val FAKE_MTB_FILE_PATH = "mv64e-mtb-fake-patient.json"
-        val CLEAN_PATIENT_ID = "e14bf9b6-7982-4933-a648-cfdea6484f1c"
+        val CLEAN_PATIENT_ID = "aca5a971-28be-4089-8128-0036a4fe6f1a"
 
         private fun fakeMtbFile(): Mtb {
             val mtbFile = ClassPathResource(FAKE_MTB_FILE_PATH).inputStream
diff --git a/src/test/resources/mv64e-mtb-fake-patient.json b/src/test/resources/mv64e-mtb-fake-patient.json
index 5895be5..291f22d 100644
--- a/src/test/resources/mv64e-mtb-fake-patient.json
+++ b/src/test/resources/mv64e-mtb-fake-patient.json
@@ -1,12 +1,12 @@
 {
   "patient": {
-    "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+    "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
     "gender": {
       "code": "male",
       "display": "Männlich",
       "system": "Gender"
     },
-    "birthDate": "1993-08-01",
+    "birthDate": "1961-09-01",
     "healthInsurance": {
       "type": {
         "code": "GKV",
@@ -24,7 +24,7 @@
       "municipalityCode": "12345"
     },
     "age": {
-      "value": 31,
+      "value": 63,
       "unit": "Years"
     },
     "vitalStatus": {
@@ -35,17 +35,17 @@
   },
   "episodesOfCare": [
     {
-      "id": "dc4d1b2c-7468-4a4a-8fbd-1b0bb645c082",
+      "id": "5481850f-f266-4d2f-8fbc-6bb790680d8f",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "period": {
-        "start": "2024-11-30"
+        "start": "2024-12-24"
       },
       "diagnoses": [
         {
-          "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
+          "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
           "type": "MTBDiagnosis"
         }
       ]
@@ -53,12 +53,12 @@
   ],
   "diagnoses": [
     {
-      "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
+      "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
-      "recordedOn": "2022-09-01",
+      "recordedOn": "2023-03-01",
       "type": {
         "history": [
           {
@@ -67,35 +67,35 @@
               "display": "Hauptdiagnose",
               "system": "dnpm-dip/mtb/diagnosis/type"
             },
-            "date": "2022-09-01"
+            "date": "2023-03-01"
           }
         ]
       },
       "code": {
-        "code": "C57.0",
-        "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+        "code": "C50.1",
+        "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
         "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
         "version": "2025"
       },
       "topography": {
-        "code": "C57.0",
-        "display": "Eileiter",
+        "code": "C50.1",
+        "display": "Zentraler Drüsenkörper der Brust",
         "system": "urn:oid:2.16.840.1.113883.6.43.1",
         "version": "Zweite Revision"
       },
       "grading": {
         "history": [
           {
-            "date": "2022-09-01",
+            "date": "2023-03-01",
             "codes": [
               {
-                "code": "4",
-                "display": "4 = undifferenziert",
+                "code": "U",
+                "display": "U = unbekannt",
                 "system": "https://www.basisdatensatz.de/feld/161/grading"
               },
               {
-                "code": "1",
-                "display": "Pilocytic astrocytoma",
+                "code": "2",
+                "display": "Diffuse astrocytoma",
                 "system": "dnpm-dip/mtb/who-grading-cns-tumors",
                 "version": "2021"
               }
@@ -106,7 +106,7 @@
       "staging": {
         "history": [
           {
-            "date": "2022-09-01",
+            "date": "2023-03-01",
             "method": {
               "code": "clinical",
               "display": "Klinisch",
@@ -118,18 +118,18 @@
                 "system": "UICC"
               },
               "nodes": {
-                "code": "N3",
+                "code": "N2",
                 "system": "UICC"
               },
               "metastasis": {
-                "code": "M0",
+                "code": "Mx",
                 "system": "UICC"
               }
             },
             "otherClassifications": [
               {
-                "code": "local",
-                "display": "Lokal",
+                "code": "unknown",
+                "display": "Unbekannt",
                 "system": "dnpm-dip/mtb/diagnosis/kds-tumor-spread"
               }
             ]
@@ -137,8 +137,8 @@
         ]
       },
       "guidelineTreatmentStatus": {
-        "code": "no-guidelines-available",
-        "display": "Keine Leitlinien vorhanden",
+        "code": "unknown",
+        "display": "Unbekannt",
         "system": "dnpm-dip/mtb/diagnosis/guideline-treatment-status"
       },
       "notes": [
@@ -146,30 +146,44 @@
       ]
     }
   ],
+  "familyMemberHistories": [
+    {
+      "id": "f982b161-f8a3-4b5b-a390-1ef0d84efc1b",
+      "patient": {
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
+        "type": "Patient"
+      },
+      "relationship": {
+        "code": "EXT",
+        "display": "Verwandter weiteren Grades",
+        "system": "dnpm-dip/mtb/family-meber-history/relationship-type"
+      }
+    }
+  ],
   "guidelineTherapies": [
     {
-      "id": "b63bcd3e-1bbb-425d-bd4f-03820036e249",
+      "id": "0c696b1a-d123-419b-9a6f-e79322392f4e",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "reason": {
-        "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
-        "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+        "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+        "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
         "type": "MTBDiagnosis"
       },
-      "therapyLine": 8,
+      "therapyLine": 3,
       "intent": {
         "code": "X",
         "display": "Keine Angabe",
         "system": "dnpm-dip/therapy/intent"
       },
       "category": {
-        "code": "S",
-        "display": "Sonstiges",
+        "code": "I",
+        "display": "Intraopterativ",
         "system": "dnpm-dip/therapy/category"
       },
-      "recordedOn": "2025-05-30",
+      "recordedOn": "2025-06-24",
       "status": {
         "code": "stopped",
         "display": "Abgebrochen",
@@ -181,13 +195,13 @@
         "system": "dnpm-dip/therapy/status-reason"
       },
       "period": {
-        "start": "2024-05-30",
-        "end": "2024-08-22"
+        "start": "2024-04-24",
+        "end": "2024-12-18"
       },
       "medication": [
         {
-          "code": "L01XX57",
-          "display": "Plitidepsin",
+          "code": "L01EX02",
+          "display": "Sorafenib",
           "system": "http://fhir.de/CodeSystem/bfarm/atc",
           "version": "2025"
         }
@@ -197,28 +211,28 @@
       ]
     },
     {
-      "id": "d7de61c1-a5cc-429b-9c6f-e47765828f90",
+      "id": "da26f4c4-834e-4f6a-86eb-4df13c4a442f",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "reason": {
-        "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
-        "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+        "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+        "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
         "type": "MTBDiagnosis"
       },
-      "therapyLine": 5,
+      "therapyLine": 4,
       "intent": {
-        "code": "P",
-        "display": "Palliativ",
+        "code": "X",
+        "display": "Keine Angabe",
         "system": "dnpm-dip/therapy/intent"
       },
       "category": {
-        "code": "S",
-        "display": "Sonstiges",
+        "code": "A",
+        "display": "Adjuvant",
         "system": "dnpm-dip/therapy/category"
       },
-      "recordedOn": "2025-05-30",
+      "recordedOn": "2025-06-24",
       "status": {
         "code": "stopped",
         "display": "Abgebrochen",
@@ -230,13 +244,13 @@
         "system": "dnpm-dip/therapy/status-reason"
       },
       "period": {
-        "start": "2024-02-29",
-        "end": "2024-10-03"
+        "start": "2024-06-24",
+        "end": "2025-02-24"
       },
       "medication": [
         {
-          "code": "L01XX29",
-          "display": "Denileukindiftitox",
+          "code": "L01EX13",
+          "display": "Gilteritinib",
           "system": "http://fhir.de/CodeSystem/bfarm/atc",
           "version": "2025"
         }
@@ -248,14 +262,14 @@
   ],
   "guidelineProcedures": [
     {
-      "id": "960c989f-12f0-4592-96a8-fcb55938cd38",
+      "id": "09ac6bfb-05bb-4c8f-b65a-dae96407939c",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "reason": {
-        "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
-        "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+        "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+        "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
         "type": "MTBDiagnosis"
       },
       "therapyLine": 3,
@@ -265,23 +279,63 @@
         "system": "dnpm-dip/therapy/intent"
       },
       "code": {
+        "code": "nuclear-medicine",
+        "display": "Nuklearmedizinische Therapie",
+        "system": "dnpm-dip/mtb/procedure/type"
+      },
+      "status": {
+        "code": "stopped",
+        "display": "Abgebrochen",
+        "system": "dnpm-dip/therapy/status"
+      },
+      "statusReason": {
+        "code": "patient-death",
+        "display": "Tod",
+        "system": "dnpm-dip/therapy/status-reason"
+      },
+      "recordedOn": "2025-06-24",
+      "period": {
+        "start": "2024-12-24"
+      },
+      "notes": [
+        "Notes on the therapeutic procedure..."
+      ]
+    },
+    {
+      "id": "1d12955f-216f-4731-8a37-e2eca4c2a735",
+      "patient": {
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
+        "type": "Patient"
+      },
+      "reason": {
+        "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+        "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
+        "type": "MTBDiagnosis"
+      },
+      "therapyLine": 1,
+      "intent": {
+        "code": "S",
+        "display": "Sonstiges",
+        "system": "dnpm-dip/therapy/intent"
+      },
+      "code": {
         "code": "surgery",
         "display": "OP",
         "system": "dnpm-dip/mtb/procedure/type"
       },
       "status": {
-        "code": "on-going",
-        "display": "Laufend",
+        "code": "completed",
+        "display": "Abgeschlossen",
         "system": "dnpm-dip/therapy/status"
       },
       "statusReason": {
-        "code": "payment-pending",
-        "display": "Kostenübernahme noch ausstehend",
+        "code": "progression",
+        "display": "Progression",
         "system": "dnpm-dip/therapy/status-reason"
       },
-      "recordedOn": "2025-05-30",
+      "recordedOn": "2025-06-24",
       "period": {
-        "start": "2024-11-30"
+        "start": "2024-12-24"
       },
       "notes": [
         "Notes on the therapeutic procedure..."
@@ -290,28 +344,28 @@
   ],
   "performanceStatus": [
     {
-      "id": "2d5108a3-600c-4153-8600-0427ad00d8a9",
+      "id": "7cf3d19b-a537-47e4-b7f0-d324e8b1ad70",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
-      "effectiveDate": "2025-05-30",
+      "effectiveDate": "2025-06-24",
       "value": {
-        "code": "5",
-        "display": "ECOG 5",
+        "code": "1",
+        "display": "ECOG 1",
         "system": "ECOG-Performance-Status"
       }
     }
   ],
   "specimens": [
     {
-      "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+      "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "diagnosis": {
-        "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
+        "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
         "type": "MTBDiagnosis"
       },
       "type": {
@@ -320,15 +374,15 @@
         "system": "dnpm-dip/mtb/tumor-specimen/type"
       },
       "collection": {
-        "date": "2025-05-30",
+        "date": "2025-06-24",
         "method": {
           "code": "unknown",
           "display": "Unbekannt",
           "system": "dnpm-dip/mtb/tumor-specimen/collection/method"
         },
         "localization": {
-          "code": "primary-tumor",
-          "display": "Primärtumor",
+          "code": "unknown",
+          "display": "Unbekannt",
           "system": "dnpm-dip/mtb/tumor-specimen/collection/localization"
         }
       }
@@ -336,9 +390,9 @@
   ],
   "priorDiagnosticReports": [
     {
-      "id": "c02f0997-c43f-4da0-819e-d7ae7370d78d",
+      "id": "0209a1fa-3948-4bc5-a2f5-988818057544",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "performer": {
@@ -346,14 +400,14 @@
         "display": "Molekular-Pathologie UKx",
         "type": "Institute"
       },
-      "issuedOn": "2025-05-30",
+      "issuedOn": "2025-06-24",
       "specimen": {
-        "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+        "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
         "type": "TumorSpecimen"
       },
       "type": {
-        "code": "karyotyping",
-        "display": "Karyotyping",
+        "code": "fusion-panel",
+        "display": "Fusionspanel",
         "system": "dnpm-dip/mtb/molecular-diagnostics/type"
       },
       "results": [
@@ -363,43 +417,43 @@
   ],
   "histologyReports": [
     {
-      "id": "791de8a5-b766-42d5-9454-12fbfe25ad92",
+      "id": "1c51bb6f-b551-43a4-9923-6db7fe36440c",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "specimen": {
-        "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+        "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
         "type": "TumorSpecimen"
       },
-      "issuedOn": "2025-05-30",
+      "issuedOn": "2025-06-24",
       "results": {
         "tumorMorphology": {
-          "id": "699db4c1-74a1-4c0f-bc20-275f85abfd20",
+          "id": "a177e88e-af76-45c8-ba93-e2f2339888a0",
           "patient": {
-            "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+            "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
             "type": "Patient"
           },
           "specimen": {
-            "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+            "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
             "type": "TumorSpecimen"
           },
           "value": {
-            "code": "8891/0",
-            "display": "Epitheloides Leiomyom",
+            "code": "9719/3",
+            "display": "Nasales NK/T-Zell-Lymphom",
             "system": "urn:oid:2.16.840.1.113883.6.43.1",
             "version": "Zweite Revision"
           },
           "note": "Notes..."
         },
         "tumorCellContent": {
-          "id": "5c408779-8f1c-4c44-a3f1-0bee32a0b7f1",
+          "id": "32605a2f-4c5c-4f5a-9909-326955405fe0",
           "patient": {
-            "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+            "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
             "type": "Patient"
           },
           "specimen": {
-            "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+            "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
             "type": "TumorSpecimen"
           },
           "method": {
@@ -407,61 +461,57 @@
             "display": "Histologisch",
             "system": "dnpm-dip/mtb/tumor-cell-content/method"
           },
-          "value": 0.022777185931090127
+          "value": 0.40875903241796807
         }
       }
     }
   ],
   "ihcReports": [
     {
-      "id": "d913c59b-7788-4931-a24c-5a71995ee77b",
+      "id": "ced8a836-262e-4067-b272-94c8f9222446",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "specimen": {
-        "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+        "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
         "type": "TumorSpecimen"
       },
-      "issuedOn": "2025-05-30",
-      "journalId": "7f39e2f3-6b0f-486d-b2d2-a1c8c4ec0493",
-      "blockIds": [
-        "a91d53a8-7949-4233-b710-1f1b456ff8c7"
-      ],
+      "issuedOn": "2025-06-24",
       "results": {
         "proteinExpression": [
           {
-            "id": "60538b11-9da7-4248-a878-00dbfe31cf37",
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+              "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
               "type": "Patient"
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             "protein": {
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-              "display": "ABCA4",
+              "code": "HGNC:3942",
+              "display": "MTOR",
               "system": "https://www.genenames.org/"
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-              "display": "2+",
+              "code": "not-exp",
+              "display": "Nicht exprimiert",
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-            "tpsScore": 15,
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             "icScore": {
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-              "display": ">= 10%",
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             "tcScore": {
-              "code": "5",
-              "display": ">= 50%",
+              "code": "6",
+              "display": ">= 75%",
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+            "id": "38ac3c86-7d13-4d5d-a85d-7d79846aa85d",
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+              "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
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@@ -470,42 +520,42 @@
               "system": "https://www.genenames.org/"
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             "value": {
-              "code": "not-exp",
-              "display": "Nicht exprimiert",
+              "code": "3+",
+              "display": "3+",
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-              "code": "5",
-              "display": ">= 50%",
+              "code": "1",
+              "display": ">= 1%",
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-            "id": "edd1cb04-8c1a-49f7-bb88-36ee576ade21",
+            "id": "002dd577-7a1e-4e47-ae63-bc84e641565e",
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+              "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
               "type": "Patient"
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             "protein": {
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-              "display": "ATRX",
+              "code": "HGNC:34",
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               "system": "https://www.genenames.org/"
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-              "display": "3+",
+              "code": "not-exp",
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@@ -515,14 +565,14 @@
             }
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+              "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
               "type": "Patient"
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             "protein": {
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-              "display": "ABCA3",
+              "code": "HGNC:3690",
+              "display": "FGFR3",
               "system": "https://www.genenames.org/"
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@@ -530,10 +580,10 @@
               "display": "Nicht exprimiert",
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-            "tpsScore": 81,
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@@ -543,30 +593,58 @@
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               "type": "Patient"
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             "protein": {
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-              "display": "BRCA1",
+              "code": "HGNC:1753",
+              "display": "CDH13",
               "system": "https://www.genenames.org/"
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-              "display": "1+",
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+              "display": "untersucht, kein Ergebnis",
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+              "display": ">= 10%",
+              "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score"
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+              "type": "Patient"
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+              "display": "BRAF",
+              "system": "https://www.genenames.org/"
+            },
+            "value": {
+              "code": "not-exp",
+              "display": "Nicht exprimiert",
+              "system": "dnpm-dip/mtb/ihc/protein-expression/result"
+            },
+            "tpsScore": 81,
+            "icScore": {
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-              "display": ">= 50%",
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@@ -577,19 +655,19 @@
   ],
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         "type": "TumorSpecimen"
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-      "issuedOn": "2025-05-30",
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-        "display": "Single",
+        "code": "genome-long-read",
+        "display": "Genome long-read",
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@@ -597,19 +675,19 @@
           "kitType": "Kit Type",
           "kitManufacturer": "Manufacturer",
           "sequencer": "Sequencer",
-          "referenceGenome": "HG38",
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@@ -617,36 +695,36 @@
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@@ -656,20 +734,20 @@
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@@ -679,25 +757,74 @@
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@@ -708,19 +835,19 @@
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@@ -728,48 +855,48 @@
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-                "display": "splicing region",
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@@ -777,74 +904,74 @@
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-              "display": "KRAS",
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-                "display": "Intergenic",
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               {
@@ -1309,97 +1488,72 @@
                 "system": "https://www.genenames.org/"
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-                "system": "https://www.genenames.org/"
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-                "code": "HGNC:3236",
-                "display": "EGFR",
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                 "system": "https://www.genenames.org/"
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               {
-                "code": "HGNC:6407",
-                "display": "KRAS",
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               "type": "Patient"
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-            "chromosome": "chr22",
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-                "code": "splicing-region",
-                "display": "splicing region",
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-                "code": "HGNC:6407",
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+                "code": "HGNC:1100",
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@@ -1411,11 +1565,6 @@
                 "code": "HGNC:3942",
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@@ -1426,8 +1575,8 @@
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-                "code": "HGNC:11998",
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@@ -1436,132 +1585,170 @@
                 "system": "https://www.genenames.org/"
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               {
-                "code": "HGNC:1753",
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+                "code": "HGNC:25662",
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-                "code": "HGNC:21597",
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@@ -1572,29 +1759,29 @@
               }
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+              "chromosome": "chr10",
               "gene": {
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-                "display": "BRAF",
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               "chromosome": "chr19",
               "gene": {
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-                "display": "EGFR",
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@@ -1605,97 +1792,105 @@
               }
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-                "display": "Intronic",
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@@ -1704,86 +1899,95 @@
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@@ -2032,148 +2236,78 @@
   ],
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-        "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
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-          "display": "Andere",
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-            "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
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               "system": "dnpm-dip/mtb/level-of-evidence/grading"
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-                "display": "iv",
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                 "type": "Publication"
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+            "code": "SO",
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           "medication": [
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-              "display": "Edrecolomab",
+              "code": "L01XX77",
+              "display": "Adagrasib",
               "system": "http://fhir.de/CodeSystem/bfarm/atc",
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@@ -2186,12 +2320,12 @@
           "supportingVariants": [
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               "gene": {
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-                "display": "ABRAXAS1",
+                "code": "HGNC:11998",
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@@ -2200,57 +2334,57 @@
       ],
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-            "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+            "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+            "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
             "type": "MTBDiagnosis"
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-          "issuedOn": "2025-05-30",
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-              "display": "m1A",
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               "system": "dnpm-dip/mtb/level-of-evidence/grading"
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-                "code": "iv",
-                "display": "iv",
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-                "id": "45577081",
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           "code": {
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-            "display": "Wait and see",
+            "code": "AS",
+            "display": "Active Surveillance",
             "system": "dnpm-dip/mtb/recommendation/procedure/category"
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               "variant": {
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+                "id": "828dfee4-37e4-485a-8c6f-49f863903f3f",
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               },
               "gene": {
-                "code": "HGNC:25829",
-                "display": "ABRAXAS1",
+                "code": "HGNC:886",
+                "display": "ATRX",
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@@ -2259,46 +2393,46 @@
       ],
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-            "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+            "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+            "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
             "type": "MTBDiagnosis"
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-          "issuedOn": "2025-05-30",
+          "issuedOn": "2025-06-24",
           "levelOfEvidence": {
             "grading": {
-              "code": "m2A",
-              "display": "m2A",
+              "code": "m2B",
+              "display": "m2B",
               "system": "dnpm-dip/mtb/level-of-evidence/grading"
             },
             "addendums": [
               {
-                "code": "iv",
-                "display": "iv",
+                "code": "R",
+                "display": "R",
                 "system": "dnpm-dip/mtb/level-of-evidence/addendum"
               }
             ],
             "publications": [
               {
-                "id": "482370142",
+                "id": "1802087682",
                 "system": "https://pubmed.ncbi.nlm.nih.gov",
                 "type": "Publication"
               }
             ]
           },
           "priority": {
-            "code": "4",
-            "display": "4",
+            "code": "1",
+            "display": "1",
             "system": "dnpm-dip/recommendation/priority"
           },
           "study": [
             {
-              "id": "8547-845744-34-56",
+              "id": "0509-104679-07-52",
               "system": "Eudra-CT",
               "type": "Study"
             }
@@ -2306,12 +2440,12 @@
           "supportingVariants": [
             {
               "variant": {
-                "id": "4705fb0d-d429-47d6-8191-c07d06d16c7a",
+                "id": "a9487572-a2a5-4074-ba8b-1e73cf92b378",
                 "type": "Variant"
               },
               "gene": {
-                "code": "HGNC:25662",
-                "display": "AAGAB",
+                "code": "HGNC:11998",
+                "display": "TP53",
                 "system": "https://www.genenames.org/"
               }
             }
@@ -2320,30 +2454,30 @@
       ],
       "histologyReevaluationRequests": [
         {
-          "id": "a641f201-fa1e-4650-8fba-adf3665040ed",
+          "id": "38f2133a-f1cf-4af6-b441-c21953e43ed3",
           "patient": {
-            "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+            "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
             "type": "Patient"
           },
           "specimen": {
-            "id": "c59253e3-3c11-40bd-bc35-7c089f734862",
+            "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51",
             "type": "TumorSpecimen"
           },
-          "issuedOn": "2025-05-30"
+          "issuedOn": "2025-06-24"
         }
       ],
       "rebiopsyRequests": [
         {
-          "id": "2501cd78-c360-40c1-9ced-455fa7172191",
+          "id": "0860944d-ede1-453b-b7ea-b13ea0fb1d2f",
           "patient": {
-            "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+            "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
             "type": "Patient"
           },
           "tumorEntity": {
-            "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
+            "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
             "type": "MTBDiagnosis"
           },
-          "issuedOn": "2025-05-30"
+          "issuedOn": "2025-06-24"
         }
       ],
       "notes": [
@@ -2353,79 +2487,45 @@
   ],
   "followUps": [
     {
-      "date": "2025-02-07",
+      "date": "2025-06-03",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
-      "lastContactDate": "2025-02-07"
+      "lastContactDate": "2025-06-03"
     }
   ],
   "claims": [
     {
-      "id": "4aa57f09-d47a-4916-852e-c79175a0eca7",
+      "id": "5ec237d4-4857-475a-9931-0aa374a93634",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "recommendation": {
-        "id": "8c9e7e7f-daea-4b7b-ad72-6ef6be070f95",
+        "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9",
         "type": "MTBMedicationRecommendation"
       },
-      "issuedOn": "2025-05-30",
+      "issuedOn": "2025-06-24",
       "stage": {
-        "code": "revocation",
-        "display": "Widerspruch",
-        "system": "dnpm-dip/mtb/claim/stage"
-      }
-    },
-    {
-      "id": "fa9b668c-c39d-42a9-bdb2-410bc3f4a361",
-      "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
-        "type": "Patient"
-      },
-      "recommendation": {
-        "id": "5adb8293-f9d1-4e65-bdcf-9d4803bd9d1c",
-        "type": "MTBMedicationRecommendation"
-      },
-      "issuedOn": "2025-05-30",
-      "stage": {
-        "code": "initial-claim",
-        "display": "Erstantrag",
+        "code": "unknown",
+        "display": "Unbekannt",
         "system": "dnpm-dip/mtb/claim/stage"
       }
     }
   ],
   "claimResponses": [
     {
-      "id": "db18a72a-293e-4f2d-bfe5-273776f8286b",
+      "id": "fed8817e-708a-4230-a7e1-95594b67e5ce",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "claim": {
-        "id": "4aa57f09-d47a-4916-852e-c79175a0eca7",
+        "id": "5ec237d4-4857-475a-9931-0aa374a93634",
         "type": "Claim"
       },
-      "issuedOn": "2025-05-30",
-      "status": {
-        "code": "accepted",
-        "display": "Angenommen",
-        "system": "dnpm-dip/mtb/claim-response/status"
-      }
-    },
-    {
-      "id": "ff5f495e-20c6-4c18-b150-4799343049c4",
-      "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
-        "type": "Patient"
-      },
-      "claim": {
-        "id": "fa9b668c-c39d-42a9-bdb2-410bc3f4a361",
-        "type": "Claim"
-      },
-      "issuedOn": "2025-05-30",
+      "issuedOn": "2025-06-24",
       "status": {
         "code": "accepted",
         "display": "Angenommen",
@@ -2437,36 +2537,41 @@
     {
       "history": [
         {
-          "id": "bc0b340d-17ea-4598-ad69-38d309e47182",
+          "id": "0b2347b7-3b85-442d-aa46-e9c5c9ee7802",
           "patient": {
-            "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+            "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
             "type": "Patient"
           },
           "reason": {
-            "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
-            "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
+            "id": "c1731d5e-6cca-4f8e-bca6-de233926106e",
+            "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse",
             "type": "MTBDiagnosis"
           },
           "intent": {
-            "code": "X",
-            "display": "Keine Angabe",
+            "code": "P",
+            "display": "Palliativ",
             "system": "dnpm-dip/therapy/intent"
           },
           "category": {
-            "code": "N",
-            "display": "Neoadjuvant",
+            "code": "S",
+            "display": "Sonstiges",
             "system": "dnpm-dip/therapy/category"
           },
           "basedOn": {
-            "id": "8c9e7e7f-daea-4b7b-ad72-6ef6be070f95",
+            "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9",
             "type": "MTBMedicationRecommendation"
           },
-          "recordedOn": "2025-05-30",
+          "recordedOn": "2025-06-24",
           "status": {
-            "code": "on-going",
-            "display": "Laufend",
+            "code": "stopped",
+            "display": "Abgebrochen",
             "system": "dnpm-dip/therapy/status"
           },
+          "statusReason": {
+            "code": "progression",
+            "display": "Progression",
+            "system": "dnpm-dip/therapy/status-reason"
+          },
           "recommendationFulfillmentStatus": {
             "code": "partial",
             "display": "Partiell",
@@ -2478,74 +2583,13 @@
             "system": "dnpm-dip/therapy/dosage-density"
           },
           "period": {
-            "start": "2024-11-08",
-            "end": "2025-05-30"
+            "start": "2025-03-18",
+            "end": "2025-06-24"
           },
           "medication": [
             {
-              "code": "L01EX01",
-              "display": "Sunitinib",
-              "system": "http://fhir.de/CodeSystem/bfarm/atc",
-              "version": "2025"
-            }
-          ],
-          "notes": [
-            "Notes on the therapy..."
-          ]
-        }
-      ]
-    },
-    {
-      "history": [
-        {
-          "id": "e3d4b435-0531-4d75-827c-0da914f054dd",
-          "patient": {
-            "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
-            "type": "Patient"
-          },
-          "reason": {
-            "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
-            "display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
-            "type": "MTBDiagnosis"
-          },
-          "intent": {
-            "code": "K",
-            "display": "Kurativ",
-            "system": "dnpm-dip/therapy/intent"
-          },
-          "category": {
-            "code": "A",
-            "display": "Adjuvant",
-            "system": "dnpm-dip/therapy/category"
-          },
-          "basedOn": {
-            "id": "5adb8293-f9d1-4e65-bdcf-9d4803bd9d1c",
-            "type": "MTBMedicationRecommendation"
-          },
-          "recordedOn": "2025-05-30",
-          "status": {
-            "code": "completed",
-            "display": "Abgeschlossen",
-            "system": "dnpm-dip/therapy/status"
-          },
-          "recommendationFulfillmentStatus": {
-            "code": "complete",
-            "display": "Komplett",
-            "system": "dnpm-dip/therapy/recommendation-fulfillment-status"
-          },
-          "dosage": {
-            "code": "over-50%",
-            "display": ">= 50 %",
-            "system": "dnpm-dip/therapy/dosage-density"
-          },
-          "period": {
-            "start": "2024-10-25",
-            "end": "2025-05-30"
-          },
-          "medication": [
-            {
-              "code": "L01FX01",
-              "display": "Edrecolomab",
+              "code": "L01XX77",
+              "display": "Adagrasib",
               "system": "http://fhir.de/CodeSystem/bfarm/atc",
               "version": "2025"
             }
@@ -2559,44 +2603,22 @@
   ],
   "responses": [
     {
-      "id": "1bcd9695-739f-451b-a403-7def6fa43614",
+      "id": "70c6b774-ca26-4837-b424-5fc37e9a1548",
       "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
+        "id": "aca5a971-28be-4089-8128-0036a4fe6f1a",
         "type": "Patient"
       },
       "therapy": {
-        "id": "bc0b340d-17ea-4598-ad69-38d309e47182",
+        "id": "0b2347b7-3b85-442d-aa46-e9c5c9ee7802",
         "type": "MTBSystemicTherapy"
       },
-      "effectiveDate": "2025-02-07",
+      "effectiveDate": "2025-06-03",
       "method": {
         "code": "RANO",
         "display": "Nach RANO-Kriterien",
         "system": "dnpm-dip/mtb/response/method"
       },
       "value": {
-        "code": "PR",
-        "display": "Partial Response",
-        "system": "RECIST"
-      }
-    },
-    {
-      "id": "89f6c606-0ec6-4b1e-a316-56a16eb52ea2",
-      "patient": {
-        "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
-        "type": "Patient"
-      },
-      "therapy": {
-        "id": "e3d4b435-0531-4d75-827c-0da914f054dd",
-        "type": "MTBSystemicTherapy"
-      },
-      "effectiveDate": "2024-12-27",
-      "method": {
-        "code": "RECIST",
-        "display": "Nach RECIST-Kriterien",
-        "system": "dnpm-dip/mtb/response/method"
-      },
-      "value": {
         "code": "SD",
         "display": "Stable Disease",
         "system": "RECIST"