diff options
| author | Paul-Christian Volkmer | 2025-12-10 14:06:41 +0100 |
|---|---|---|
| committer | GitHub | 2025-12-10 13:06:41 +0000 |
| commit | f1021fbfb2778c8c8b811e2f36347f247df99f75 (patch) | |
| tree | 323c456448fcb9c0523d3646a7c3a03e5e4eaf6e /src/test | |
| parent | 84cfa403d832b9eb3d968092808f0889b87b9df6 (diff) | |
test: update fake patient data (#224)
This is required due to value format changes in DNPM:DIP for TNM etc.
Diffstat (limited to 'src/test')
| -rw-r--r-- | src/test/resources/mv64e-mtb-fake-patient.json | 2558 |
1 files changed, 1778 insertions, 780 deletions
diff --git a/src/test/resources/mv64e-mtb-fake-patient.json b/src/test/resources/mv64e-mtb-fake-patient.json index 43fc2ef..a9cdf18 100644 --- a/src/test/resources/mv64e-mtb-fake-patient.json +++ b/src/test/resources/mv64e-mtb-fake-patient.json @@ -1,13 +1,13 @@ { "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "gender": { "code": "female", "display": "Weiblich", "system": "Gender" }, - "birthDate": "1962-10-21", - "dateOfDeath": "2009-10-21", + "birthDate": "1957-01-26", + "dateOfDeath": "2007-01-26", "healthInsurance": { "type": { "code": "GKV", @@ -25,7 +25,7 @@ "municipalityCode": "12345" }, "age": { - "value": 47, + "value": 50, "unit": "Years" }, "vitalStatus": { @@ -36,17 +36,17 @@ }, "episodesOfCare": [ { - "id": "d8b68856-3ba2-4d43-9653-6924897f5eab", + "id": "85fff8b1-a5be-4c87-80ef-95ea96b6f8ea", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "period": { - "start": "2025-01-09" + "start": "2025-06-10" }, "diagnoses": [ { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", "type": "MTBDiagnosis" } ] @@ -54,12 +54,12 @@ ], "diagnoses": [ { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "recordedOn": "2007-10-21", + "recordedOn": "2003-09-26", "type": { "history": [ { @@ -68,35 +68,35 @@ "display": "Hauptdiagnose", "system": "dnpm-dip/mtb/diagnosis/type" }, - "date": "2007-10-21" + "date": "2003-09-26" } ] }, "code": { - "code": "C72.5", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "code": "C53.8", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm", "version": "2025" }, "topography": { - "code": "C72.5", - "display": "Hirnnerven o.n.A.", + "code": "C53.8", + "display": "Cervix uteri, mehrere Teilbereiche überlappend", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "grading": { "history": [ { - "date": "2007-10-21", + "date": "2003-09-26", "codes": [ { - "code": "3", - "display": "3 = schlecht differenziert", + "code": "2", + "display": "2 = mäßig differenziert", "system": "https://www.basisdatensatz.de/feld/161/grading" }, { - "code": "3", - "display": "Anaplastic astrocytoma", + "code": "4", + "display": "Glioblastoma", "system": "dnpm-dip/mtb/who-grading-cns-tumors", "version": "2021" } @@ -107,7 +107,7 @@ "staging": { "history": [ { - "date": "2007-10-21", + "date": "2003-09-26", "method": { "code": "clinical", "display": "Klinisch", @@ -119,18 +119,18 @@ "system": "UICC" }, "nodes": { - "code": "Nx", + "code": "N0", "system": "UICC" }, "metastasis": { - "code": "M0", + "code": "M1", "system": "UICC" } }, "otherClassifications": [ { - "code": "unknown", - "display": "Unbekannt", + "code": "metastasized", + "display": "Metastasiert", "system": "dnpm-dip/mtb/diagnosis/kds-tumor-spread" } ] @@ -138,10 +138,16 @@ ] }, "guidelineTreatmentStatus": { - "code": "impossible", - "display": "Leitlinientherapie nicht möglich", + "code": "non-exhausted", + "display": "Leitlinien nicht ausgeschöpft", "system": "dnpm-dip/mtb/diagnosis/guideline-treatment-status" }, + "histology": [ + { + "id": "549143c4-aacb-42aa-914f-5ddf8adf1046", + "type": "HistologyReport" + } + ], "notes": [ "Notes on the tumor diagnosis..." ] @@ -149,9 +155,9 @@ ], "familyMemberHistories": [ { - "id": "0eac775e-ea13-49d4-a390-a5e99744ac6b", + "id": "40020f7c-eb7d-494a-a689-e10e823dcaaf", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "relationship": { @@ -163,28 +169,28 @@ ], "guidelineTherapies": [ { - "id": "af77fcc8-bcdc-41fb-9989-c4ad2fd9ce3c", + "id": "e6e677fa-c439-4647-810b-84960334505c", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "type": "MTBDiagnosis" }, - "therapyLine": 8, + "therapyLine": 3, "intent": { - "code": "X", - "display": "Keine Angabe", + "code": "S", + "display": "Sonstiges", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "A", - "display": "Adjuvant", + "code": "N", + "display": "Neoadjuvant", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-07-09", + "recordedOn": "2025-12-10", "status": { "code": "stopped", "display": "Abgebrochen", @@ -196,62 +202,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2024-03-09", - "end": "2024-08-10" + "start": "2024-02-10", + "end": "2024-08-17" }, "medication": [ { - "code": "L01XX58", - "display": "Epacadostat", - "system": "http://fhir.de/CodeSystem/bfarm/atc", - "version": "2025" - } - ], - "notes": [ - "Notes on the therapy..." - ] - }, - { - "id": "f922939a-926e-4319-90e7-488ed9027d6d", - "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", - "type": "Patient" - }, - "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", - "type": "MTBDiagnosis" - }, - "therapyLine": 5, - "intent": { - "code": "X", - "display": "Keine Angabe", - "system": "dnpm-dip/therapy/intent" - }, - "category": { - "code": "I", - "display": "Intraopterativ", - "system": "dnpm-dip/therapy/category" - }, - "recordedOn": "2025-07-09", - "status": { - "code": "stopped", - "display": "Abgebrochen", - "system": "dnpm-dip/therapy/status" - }, - "statusReason": { - "code": "progression", - "display": "Progression", - "system": "dnpm-dip/therapy/status-reason" - }, - "period": { - "start": "2024-04-09", - "end": "2024-09-10" - }, - "medication": [ - { - "code": "L01EG01", - "display": "Temsirolimus", + "code": "L01EX09", + "display": "Nintedanib", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -263,25 +220,25 @@ ], "guidelineProcedures": [ { - "id": "b6d5bd15-356d-468a-a816-5fd955fc51a2", + "id": "50e3a517-90e8-4338-a484-2f9967df91be", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "type": "MTBDiagnosis" }, - "therapyLine": 2, + "therapyLine": 4, "intent": { - "code": "X", - "display": "Keine Angabe", + "code": "S", + "display": "Sonstiges", "system": "dnpm-dip/therapy/intent" }, "code": { - "code": "radio-therapy", - "display": "Strahlen-Therapie", + "code": "surgery", + "display": "OP", "system": "dnpm-dip/mtb/procedure/type" }, "status": { @@ -290,13 +247,13 @@ "system": "dnpm-dip/therapy/status" }, "statusReason": { - "code": "regular-completion-with-substance-change", - "display": "Reguläres Ende mit Substanzwechsel", + "code": "other-therapy-chosen", + "display": "Wahl einer anderen Therapie durch Behandler", "system": "dnpm-dip/therapy/status-reason" }, - "recordedOn": "2025-07-09", + "recordedOn": "2025-12-10", "period": { - "start": "2025-01-09" + "start": "2025-06-10" }, "notes": [ "Notes on the therapeutic procedure..." @@ -305,45 +262,45 @@ ], "performanceStatus": [ { - "id": "279b4954-7901-4b0b-89f3-1f90b12bcc02", + "id": "11f61599-ac83-4135-82ae-671dc956bfb0", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "effectiveDate": "2025-07-09", + "effectiveDate": "2025-12-10", "value": { - "code": "3", - "display": "ECOG 3", + "code": "2", + "display": "ECOG 2", "system": "ECOG-Performance-Status" } } ], "specimens": [ { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "diagnosis": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", "type": "MTBDiagnosis" }, "type": { - "code": "FFPE", - "display": "FFPE", + "code": "liquid-biopsy", + "display": "Liquid Biopsy", "system": "dnpm-dip/mtb/tumor-specimen/type" }, "collection": { - "date": "2025-07-09", + "date": "2025-12-10", "method": { - "code": "biopsy", - "display": "Biopsie", + "code": "cytology", + "display": "Zytologie", "system": "dnpm-dip/mtb/tumor-specimen/collection/method" }, "localization": { - "code": "local-recurrence", - "display": "Lokalrezidiv", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/tumor-specimen/collection/localization" } } @@ -351,9 +308,9 @@ ], "priorDiagnosticReports": [ { - "id": "a7f20f97-c9ea-424d-add6-605dc2461782", + "id": "ec700da6-a194-4853-be52-bc9a66a3450f", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "performer": { @@ -361,14 +318,14 @@ "display": "Molekular-Pathologie UKx", "type": "Institute" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "type": { - "code": "fusion-panel", - "display": "Fusionspanel", + "code": "array", + "display": "Array", "system": "dnpm-dip/mtb/molecular-diagnostics/type" }, "results": [ @@ -378,43 +335,43 @@ ], "histologyReports": [ { - "id": "d57816b6-18b5-485d-9d7f-fc31004c429e", + "id": "549143c4-aacb-42aa-914f-5ddf8adf1046", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "results": { "tumorMorphology": { - "id": "21f1d157-6f40-4127-9b2f-91f32fedceb0", + "id": "b3845b08-6c6b-41df-8b74-0d795c4351f0", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "value": { - "code": "9542/3", - "display": "Epitheloider maligner peripherer Nervenscheidentumor", + "code": "9181/3", + "display": "Chondroblastisches Osteosarkom [C40.-] [C41.-]", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "note": "Notes..." }, "tumorCellContent": { - "id": "81a42ef1-f9fe-4dfe-a876-cf1a262ca4ce", + "id": "268b9f18-2e62-46b6-a40b-fda09478b209", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "method": { @@ -422,34 +379,63 @@ "display": "Histologisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - "value": 0.12624946426974026 + "value": 0.9068795360732212 } } } ], "ihcReports": [ { - "id": "2046a862-66e0-4402-bb93-b64ce179d014", + "id": "7f7bd217-8281-46c2-bbee-787cbe5eea6a", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "results": { "proteinExpression": [ { - "id": "15d628bb-6e6a-435f-98dd-8bbc2f0311d1", + "id": "d431964c-45a4-40a6-b485-81693a64d1a9", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "protein": { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + "value": { + "code": "not-exp", + "display": "Nicht exprimiert", + "system": "dnpm-dip/mtb/ihc/protein-expression/result" + }, + "tpsScore": 55, + "cpsScore": 41, + "icScore": { + "code": "0", + "display": "< 1%", + "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" + }, + "tcScore": { + "code": "5", + "display": ">= 50%", + "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" + } + }, + { + "id": "37e310b4-3ed2-455c-8f39-2c1ca59f2a3f", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "protein": { + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" }, "value": { @@ -457,27 +443,28 @@ "display": "1+", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 42, + "tpsScore": 62, + "cpsScore": 53, "icScore": { "code": "1", "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "4", - "display": ">= 25%", + "code": "3", + "display": ">= 10%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "a7af8f99-b917-4498-8c95-f09818906de2", + "id": "2f184f8b-7762-42ea-9afc-1b14727e3458", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "protein": { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, "value": { @@ -485,22 +472,52 @@ "display": "1+", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 90, + "tpsScore": 79, + "cpsScore": 47, "icScore": { - "code": "0", - "display": "< 1%", + "code": "3", + "display": ">= 10%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "4", - "display": ">= 25%", + "code": "6", + "display": ">= 75%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "ea2d53e1-9a52-4fb2-87fd-b8b9acfb4017", + "id": "1c80d2f3-566d-40b4-85e1-62ec430791fd", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "protein": { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + "value": { + "code": "2+", + "display": "2+", + "system": "dnpm-dip/mtb/ihc/protein-expression/result" + }, + "tpsScore": 88, + "cpsScore": 16, + "icScore": { + "code": "1", + "display": ">= 1%", + "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" + }, + "tcScore": { + "code": "2", + "display": ">= 5%", + "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" + } + }, + { + "id": "980036a2-470d-40b0-9b8d-28751273640a", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "protein": { @@ -509,14 +526,15 @@ "system": "https://www.genenames.org/" }, "value": { - "code": "1+", - "display": "1+", + "code": "not-exp", + "display": "Nicht exprimiert", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 41, + "tpsScore": 32, + "cpsScore": 7, "icScore": { - "code": "0", - "display": "< 1%", + "code": "2", + "display": ">= 5%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { @@ -526,9 +544,9 @@ } }, { - "id": "b0794bbd-6e4e-442f-bfcf-cf2558ae3069", + "id": "a6e81d37-50e1-4cfc-b975-6c33ee7fb51c", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "protein": { @@ -541,15 +559,74 @@ "display": "untersucht, kein Ergebnis", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 83, + "tpsScore": 29, + "cpsScore": 2, + "icScore": { + "code": "2", + "display": ">= 5%", + "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" + }, + "tcScore": { + "code": "4", + "display": ">= 25%", + "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" + } + }, + { + "id": "48a1defc-c101-4f09-81cc-e41dcf6d4de6", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "protein": { + "code": "HGNC:33", + "display": "ABCA3", + "system": "https://www.genenames.org/" + }, + "value": { + "code": "1+", + "display": "1+", + "system": "dnpm-dip/mtb/ihc/protein-expression/result" + }, + "tpsScore": 98, + "cpsScore": 24, "icScore": { "code": "1", "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "5", - "display": ">= 50%", + "code": "0", + "display": "< 1%", + "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" + } + }, + { + "id": "6700b0b2-cc67-4711-aa12-04ecceb92bb6", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "protein": { + "code": "HGNC:33", + "display": "ABCA3", + "system": "https://www.genenames.org/" + }, + "value": { + "code": "3+", + "display": "3+", + "system": "dnpm-dip/mtb/ihc/protein-expression/result" + }, + "tpsScore": 62, + "cpsScore": 98, + "icScore": { + "code": "3", + "display": ">= 10%", + "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" + }, + "tcScore": { + "code": "1", + "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } } @@ -560,43 +637,43 @@ ], "msiFindings": [ { - "id": "73df8592-b79a-4277-ab5b-0d59c4af5659", + "id": "ba82a81a-dc93-4667-ba29-080a27279406", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "method": { - "code": "PCR", - "display": "PCR", + "code": "bioinformatic", + "display": "Sequenzierung", "system": "dnpm-dip/mtb/msi/method" }, - "value": 0.800039814642262, + "value": 0.14136417072841295, "interpretation": { - "code": "msi-high", - "display": "MSI high", + "code": "mmr-proficient", + "display": "MMR Proficient", "system": "dnpm-dip/mtb/msi/interpretation" } } ], "ngsReports": [ { - "id": "76003d5a-8c9e-4587-8e39-d4c785d234ea", + "id": "f98b924a-c7ad-4c23-8317-b3e65768a49b", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "type": { - "code": "genome-long-read", - "display": "Genome long-read", + "code": "exome", + "display": "Exome", "system": "dnpm-dip/ngs/type" }, "metadata": [ @@ -604,19 +681,19 @@ "kitType": "Kit Type", "kitManufacturer": "Manufacturer", "sequencer": "Sequencer", - "referenceGenome": "GRCh37", + "referenceGenome": "HG38", "pipeline": "https://github.com/pipeline-project" } ], "results": { "tumorCellContent": { - "id": "a76fbe2c-7e89-4abe-af89-884d03fec74e", + "id": "9c57f439-bacc-4491-a7cd-686615e28321", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "method": { @@ -624,36 +701,36 @@ "display": "Bioinformatisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - "value": 0.28954646267764894 + "value": 0.903078717009823 }, "tmb": { - "id": "1c94b024-1f8b-448a-a3d1-969b3e0cc9df", + "id": "a931f089-9ef1-4693-a706-a99bfa50c4dd", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "value": { - "value": 378485, + "value": 472438, "unit": "Mutations per megabase" }, "interpretation": { - "code": "intermediate", - "display": "Mittel", + "code": "low", + "display": "Niedrig", "system": "dnpm-dip/mtb/ngs/tmb/interpretation" } }, "brcaness": { - "id": "66a288cb-41c1-40c8-9c56-0c6bd351dc1d", + "id": "be145e9f-f6ab-4b7a-a7b4-435c8dfdb766", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, "value": 0.5, @@ -663,20 +740,20 @@ } }, "hrdScore": { - "id": "19947989-81e0-434b-a67e-efb465e3dce8", + "id": "fd16fc89-b492-49cd-9ed4-39f9a597c87a", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, - 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"code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, "localization": [ @@ -715,19 +841,19 @@ } ], "transcriptId": { - "value": "5d55b598-db89-48f2-8d56-9fb6548c8ac6", - "system": "https://www.ensembl.org" + "value": "fb70156b-ec81-42cb-a3c0-77a64410eed4", + "system": "https://www.ncbi.nlm.nih.gov/refseq" }, - "exonId": "9", + "exonId": "2", "position": { - "start": 504 + "start": 54 }, - "altAllele": "T", - "refAllele": "A", - "dnaChange": "c.504A>T", - "proteinChange": "p.His4_Gln5insAla", - "readDepth": 14, - "allelicFrequency": 0.4397302456613448, + "altAllele": "G", + "refAllele": "T", + "dnaChange": "c.54T>G", + "proteinChange": "p.Val7del", + "readDepth": 19, + "allelicFrequency": 0.9767328312144244, "interpretation": { "code": "1", "display": "Benign", @@ -735,48 +861,48 @@ } }, { - "id": "4ba9159c-6301-49cd-b479-4337e148c835", + "id": "66abece4-04fa-46d3-9530-3cb44689233f", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "externalIds": [ { - 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"code": "HGNC:25662", - "display": "AAGAB", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:391", - "display": "AKT1", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, { @@ -951,11 +1268,44 @@ "system": "https://www.genenames.org/" }, { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:34", "display": "ABCA4", "system": "https://www.genenames.org/" }, { + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + } + ], + "reportedFocality": "partial q-arm", + "type": { + "code": "loss", + "display": "Loss", + "system": "dnpm-dip/mtb/ngs-report/cnv/type" + }, + "copyNumberNeutralLoH": [ + { + "code": "HGNC:21597", + "display": "ACAD10", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3690", + "display": "FGFR3", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:18615", "display": "BRAFP1", "system": "https://www.genenames.org/" @@ -964,38 +1314,67 @@ "code": "HGNC:1753", "display": "CDH13", "system": "https://www.genenames.org/" - }, + } + ] + }, + { + "id": "3e3f4c67-27a0-419a-ac30-afc2d1ec1f6c", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "chromosome": "chr17", + "localization": [ { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "splicing-region", + "display": "splicing region", + "system": "dnpm-dip/variant/localization" + } + ], + "startRange": { + "start": 42185, + "end": 42227 + }, + "endRange": { + "start": 43056, + "end": 43106 + }, + "totalCopyNumber": 1, + "relativeCopyNumber": 0.6980982819550261, + "cnA": 0.9309939129189686, + "cnB": 0.9185762663924669, + "reportedAffectedGenes": [ + { + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", + "code": "HGNC:18615", + "display": "BRAFP1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:34", + "display": "ABCA4", "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", "type": { - "code": "high-level-gain", - "display": "High-level-gain", + "code": "loss", + "display": "Loss", "system": "dnpm-dip/mtb/ngs-report/cnv/type" }, "copyNumberNeutralLoH": [ { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { @@ -1004,11 +1383,6 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:1753", - "display": "CDH13", - "system": "https://www.genenames.org/" - }, - { "code": "HGNC:1100", "display": "BRCA1", "system": "https://www.genenames.org/" @@ -1019,53 +1393,38 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:34", - "display": "ABCA4", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3942", - "display": "MTOR", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" } ] }, { - "id": "9ca350f8-7def-4a6b-9251-d76cda6c9066", + "id": "ecd03275-4d29-4fa8-8ea2-64a5c3d53917", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "chromosome": "chr7", + "chromosome": "chr12", "localization": [ { - "code": "intronic", - "display": "Intronic", + "code": "coding-region", + "display": "Coding region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 33756, - "end": 33798 + "start": 46694, + "end": 46736 }, "endRange": { - "start": 33971, - "end": 34021 + "start": 47036, + "end": 47086 }, - "totalCopyNumber": 5, - "relativeCopyNumber": 0.9849081436334101, - "cnA": 0.7654754033556277, - "cnB": 0.4113320623943184, + "totalCopyNumber": 3, + "relativeCopyNumber": 0.1791784294329528, + "cnA": 0.8174197115141975, + "cnB": 0.8596463694732068, "reportedAffectedGenes": [ { "code": "HGNC:33", @@ -1073,45 +1432,50 @@ "system": "https://www.genenames.org/" }, { + "code": "HGNC:11998", + "display": "TP53", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:25829", "display": "ABRAXAS1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:6973", + "display": "MDM2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", + "code": "HGNC:1100", + "display": "BRCA1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:391", + "display": "AKT1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", "type": { - "code": "high-level-gain", - "display": "High-level-gain", + "code": "low-level-gain", + "display": "Low-level-gain", "system": "dnpm-dip/mtb/ngs-report/cnv/type" }, "copyNumberNeutralLoH": [ @@ -1121,18 +1485,8 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:11998", - "display": "TP53", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3942", - "display": "MTOR", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, { @@ -1141,24 +1495,24 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:3236", + "display": "EGFR", "system": "https://www.genenames.org/" } ] }, { - "id": "3f0d9d82-46ad-44e9-85a4-fc5fccf78dae", + "id": "881a7925-647d-4899-8e30-470a7bd7c423", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "chromosome": "chr7", + "chromosome": "chr22", "localization": [ { "code": "splicing-region", @@ -1167,17 +1521,17 @@ } ], "startRange": { - 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"code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:3690", + "display": "FGFR3", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:9967", + "display": "RET", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" } ], @@ -1233,18 +1607,13 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:1753", - "display": "CDH13", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:6973", + "display": "MDM2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, { @@ -1253,24 +1622,19 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:34", - "display": "ABCA4", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" } ] }, { - "id": "67beb706-0870-470e-b6c1-bf28662a60f6", + "id": "205c8cd8-106c-48b0-a1cb-871148b28b98", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "chromosome": "chr21", + "chromosome": "chr15", "localization": [ { "code": "regulatory-region", @@ -1279,17 +1643,17 @@ } ], "startRange": { - "start": 46825, - "end": 46867 + "start": 23260, + "end": 23302 }, "endRange": { - "start": 47805, - "end": 47855 + "start": 24009, + "end": 24059 }, - "totalCopyNumber": 4, - "relativeCopyNumber": 0.667919646926896, - "cnA": 0.6344586287700189, - "cnB": 0.5935064515068115, + "totalCopyNumber": 5, + "relativeCopyNumber": 0.9734007035075503, + "cnA": 0.6238438000255766, + "cnB": 0.23390480714640038, "reportedAffectedGenes": [ { "code": "HGNC:6973", @@ -1297,13 +1661,13 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "HGNC:76", + "display": "ABL1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, { @@ -1312,13 +1676,23 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:1753", + "display": "CDH13", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3690", + "display": "FGFR3", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, { @@ -1332,13 +1706,23 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:3942", + "display": "MTOR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3236", + "display": "EGFR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" } ], @@ -1350,23 +1734,38 @@ }, "copyNumberNeutralLoH": [ { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:25829", + "display": "ABRAXAS1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:6973", + "display": "MDM2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1777", - "display": "CDK6", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3942", + "display": "MTOR", "system": "https://www.genenames.org/" }, { @@ -1382,85 +1781,103 @@ ] }, { - "id": "302808e8-25e5-44dd-bac1-1ec3bc901fca", + "id": "96c15e3e-fe1a-4c32-ab92-26bd8814f4fa", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "chromosome": "chr15", + "chromosome": "chr8", "localization": [ { - "code": "splicing-region", - "display": "splicing region", + "code": "intergenic", + "display": "Intergenic", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 29564, - "end": 29606 + "start": 31085, + "end": 31127 }, "endRange": { - "start": 30496, - "end": 30546 + "start": 31689, + "end": 31739 }, - "totalCopyNumber": 6, - "relativeCopyNumber": 0.9554782410556386, - "cnA": 0.14914124694657616, - "cnB": 0.04403923699882417, + "totalCopyNumber": 5, + "relativeCopyNumber": 0.683510295298012, + "cnA": 0.650807528998207, + "cnB": 0.8086967985358056, "reportedAffectedGenes": [ { + "code": "HGNC:33", + "display": "ABCA3", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:11998", "display": "TP53", "system": "https://www.genenames.org/" }, { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "HGNC:18615", + "display": "BRAFP1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3236", + "display": "EGFR", "system": "https://www.genenames.org/" }, { "code": "HGNC:21597", "display": "ACAD10", "system": "https://www.genenames.org/" - }, + } + ], + "reportedFocality": "partial q-arm", + "type": { + "code": "high-level-gain", + "display": "High-level-gain", + "system": "dnpm-dip/mtb/ngs-report/cnv/type" + }, + "copyNumberNeutralLoH": [ { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { @@ -1469,6 +1886,16 @@ "system": "https://www.genenames.org/" }, { + "code": "HGNC:21597", + "display": "ACAD10", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:9967", "display": "RET", "system": "https://www.genenames.org/" @@ -1478,27 +1905,43 @@ "display": "AACS", "system": "https://www.genenames.org/" } - ], - "reportedFocality": "partial q-arm", - "type": { - "code": "high-level-gain", - "display": "High-level-gain", - "system": "dnpm-dip/mtb/ngs-report/cnv/type" + ] + }, + { + "id": "5c897989-fb79-45e7-bd8c-e0d94c371297", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" }, - "copyNumberNeutralLoH": [ + "chromosome": "chr4", + "localization": [ { - "code": "HGNC:5173", - "display": "HRAS", - "system": "https://www.genenames.org/" - }, + "code": "intronic", + "display": "Intronic", + "system": "dnpm-dip/variant/localization" + } + ], + "startRange": { + "start": 25324, + "end": 25366 + }, + "endRange": { + "start": 26077, + "end": 26127 + }, + "totalCopyNumber": 5, + "relativeCopyNumber": 0.05796622485924319, + "cnA": 0.7459722394132859, + "cnB": 0.12649365988633932, + "reportedAffectedGenes": [ { "code": "HGNC:6973", "display": "MDM2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, { @@ -1507,13 +1950,31 @@ "system": "https://www.genenames.org/" }, { + "code": "HGNC:3942", + "display": "MTOR", + "system": "https://www.genenames.org/" + } + ], + "reportedFocality": "partial q-arm", + "type": { + "code": "high-level-gain", + "display": "High-level-gain", + "system": "dnpm-dip/mtb/ngs-report/cnv/type" + }, + "copyNumberNeutralLoH": [ + { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:1777", "display": "CDK6", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, { @@ -1527,38 +1988,43 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:21597", - "display": "ACAD10", + "code": "HGNC:3942", + "display": "MTOR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3236", + "display": "EGFR", "system": "https://www.genenames.org/" } ] }, { - "id": "251c4538-efd4-41cb-ac11-7aa6004b4546", + "id": "a995b155-8639-405e-b16f-4e79979dbfef", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "chromosome": "chr6", + "chromosome": "chr18", "localization": [ { - "code": "regulatory-region", - "display": "Regulatory region", + "code": "coding-region", + "display": "Coding region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 10903, - "end": 10945 + "start": 10077, + "end": 10119 }, "endRange": { - "start": 11359, - "end": 11409 + "start": 10517, + "end": 10567 }, - "totalCopyNumber": 7, - "relativeCopyNumber": 0.3329690143900391, - "cnA": 0.6937471513244393, - "cnB": 0.07580581478248649, + "totalCopyNumber": 6, + "relativeCopyNumber": 0.44762676983108496, + "cnA": 0.8800626612773866, + "cnB": 0.9060263434558149, "reportedAffectedGenes": [ { "code": "HGNC:11998", @@ -1566,28 +2032,28 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1777", - "display": "CDK6", + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" } ], @@ -1599,16 +2065,123 @@ }, "copyNumberNeutralLoH": [ { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:391", + "display": "AKT1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:886", + "display": "ATRX", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3236", + "display": "EGFR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21597", + "display": "ACAD10", + "system": "https://www.genenames.org/" + } + ] + }, + { + "id": "9395acc5-abc3-4a98-b2ae-eeab3e3360b6", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "chromosome": "chr19", + "localization": [ + { + "code": "splicing-region", + "display": "splicing region", + "system": "dnpm-dip/variant/localization" + } + ], + "startRange": { + "start": 46919, + "end": 46961 + }, + "endRange": { + "start": 47194, + "end": 47244 + }, + "totalCopyNumber": 1, + "relativeCopyNumber": 0.13371857951636312, + "cnA": 0.42278682971724124, + "cnB": 0.7209634384392413, + "reportedAffectedGenes": [ + { + "code": "HGNC:33", + "display": "ABCA3", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:391", + "display": "AKT1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3942", + "display": "MTOR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:25662", + "display": "AAGAB", "system": "https://www.genenames.org/" }, { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + } + ], + "reportedFocality": "partial q-arm", + "type": { + "code": "loss", + "display": "Loss", + "system": "dnpm-dip/mtb/ngs-report/cnv/type" + }, + "copyNumberNeutralLoH": [ + { "code": "HGNC:25829", "display": "ABRAXAS1", "system": "https://www.genenames.org/" @@ -1619,8 +2192,8 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:391", + "display": "AKT1", "system": "https://www.genenames.org/" }, { @@ -1629,13 +2202,13 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:34", + "display": "ABCA4", "system": "https://www.genenames.org/" }, { @@ -1648,108 +2221,141 @@ ], "dnaFusions": [ { - "id": "1175b70b-b667-47b2-831d-c8537f035b47", + "id": "73aab2c8-83e1-41b0-99c6-7739738d56c2", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "localization": [ { - "code": "regulatory-region", - "display": "Regulatory region", + "code": "intronic", + "display": "Intronic", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "chromosome": "chr19", + "chromosome": "chr15", "gene": { - "code": "HGNC:21597", - "display": "ACAD10", + "code": "HGNC:6973", + "display": "MDM2", "system": "https://www.genenames.org/" }, - "position": 640 + "position": 734 }, "fusionPartner3prime": { - "chromosome": "chr7", + "chromosome": "chr21", "gene": { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, - "position": 214 + "position": 91 }, - "reportedNumReads": 8 + "reportedNumReads": 6 }, { - "id": "1554981f-5fb8-4af4-9469-9577039873a2", + "id": "75142424-46d5-48f4-b400-37fccae294c3", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "localization": [ { - "code": "splicing-region", - "display": "splicing region", + "code": "intergenic", + "display": "Intergenic", + "system": "dnpm-dip/variant/localization" + } + ], + "fusionPartner5prime": { + "chromosome": "chrMT", + "gene": { + "code": "HGNC:76", + "display": "ABL1", + "system": "https://www.genenames.org/" + }, + "position": 858 + }, + "fusionPartner3prime": { + "chromosome": "chr8", + "gene": { + "code": "HGNC:76", + "display": "ABL1", + "system": "https://www.genenames.org/" + }, + "position": 952 + }, + "reportedNumReads": 7 + }, + { + "id": "ed1be681-58f6-4dbc-84f1-ca5c85f6ef52", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "localization": [ + { + "code": "coding-region", + "display": "Coding region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - 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"position": 545 + "position": 601 }, "fusionPartner3prime": { - "chromosome": "chr22", + "chromosome": "chrX", "gene": { "code": "HGNC:21597", "display": "ACAD10", "system": "https://www.genenames.org/" }, - "position": 360 + "position": 744 }, - "reportedNumReads": 4 + "reportedNumReads": 3 }, { - "id": "1b64154c-4998-4863-be54-015dbc4e15b1", + "id": "97171497-0c9a-49b0-a999-38d6e17b1ea0", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "localization": [ @@ -1760,29 +2366,29 @@ } ], "fusionPartner5prime": { - "chromosome": "chr1", + "chromosome": "chr21", "gene": { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, - "position": 564 + "position": 671 }, "fusionPartner3prime": { - "chromosome": "chr1", + "chromosome": "chr5", "gene": { - "code": "HGNC:1777", - "display": "CDK6", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, - 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"issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "geneticCounselingRecommendation": { - "id": "23452d54-dfa9-48f7-a191-7df1b94594c2", + "id": "83a14590-f345-4ee7-96d5-70c4ddefd40c", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "reason": { - "code": "secondary-tumor", - "display": "Zweittumor", + "code": "other", + "display": "Andere", "system": "dnpm-dip/mtb/recommendation/genetic-counseling/reason" } }, "medicationRecommendations": [ { - "id": "55f1bead-15c6-4fd5-8aa8-ee4c9b2cb285", + "id": "d1e90355-b1ba-46e1-a900-e439b63caea0", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "type": "MTBDiagnosis" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "priority": { - "code": "3", - "display": "3", + "code": "4", + "display": "4", "system": "dnpm-dip/recommendation/priority" }, "levelOfEvidence": { @@ -2170,14 +2972,14 @@ }, "addendums": [ { - "code": "is", - "display": "is", + "code": "iv", + "display": "iv", "system": "dnpm-dip/mtb/level-of-evidence/addendum" } ], "publications": [ { - "id": "1525598879", + "id": "366546121", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } @@ -2185,15 +2987,15 @@ }, "category": [ { - "code": "IM", - "display": "Immun-/Antikörpertherapie", + "code": "SZ", + "display": "Stammzelltransplantation (inklusive Knochenmarktransplantation)", "system": "dnpm-dip/mtb/recommendation/systemic-therapy/category" } ], "medication": [ { - "code": "L01FX03", - "display": "Catumaxomab", + "code": "L01XX73", + "display": "Sotorasib", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -2206,12 +3008,84 @@ "supportingVariants": [ { "variant": { - "id": "4093aaf4-b5a9-4a36-a027-bf3b4a313a6f", + "id": "1553e32e-09e6-4f13-af10-379fef9531dc", "type": "Variant" }, "gene": { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:9967", + "display": "RET", + "system": "https://www.genenames.org/" + } + } + ] + }, + { + "id": "c0687be9-6c5e-44f0-b083-688f2f4e9e07", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "reason": { + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", + "type": "MTBDiagnosis" + }, + "issuedOn": "2025-12-10", + "priority": { + "code": "1", + "display": "1", + "system": "dnpm-dip/recommendation/priority" + }, + "levelOfEvidence": { + "grading": { + "code": "m1C", + "display": "m1C", + "system": "dnpm-dip/mtb/level-of-evidence/grading" + }, + "addendums": [ + { + "code": "iv", + "display": "iv", + "system": "dnpm-dip/mtb/level-of-evidence/addendum" + } + ], + "publications": [ + { + "id": "157498640", + "system": "https://pubmed.ncbi.nlm.nih.gov", + "type": "Publication" + } + ] + }, + "category": [ + { + "code": "IM", + "display": "Immun-/Antikörpertherapie", + "system": "dnpm-dip/mtb/recommendation/systemic-therapy/category" + } + ], + "medication": [ + { + "code": "L01FX09", + "display": "Mogamulizumab", + "system": "http://fhir.de/CodeSystem/bfarm/atc", + "version": "2025" + } + ], + "useType": { + "code": "sec-preventive", + "display": "Sec-preventive", + "system": "dnpm-dip/mtb/recommendation/systemic-therapy/use-type" + }, + "supportingVariants": [ + { + "variant": { + "id": "96c15e3e-fe1a-4c32-ab92-26bd8814f4fa", + "type": "Variant" + }, + "gene": { + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" } } @@ -2220,57 +3094,57 @@ ], "procedureRecommendations": [ { - "id": "57720dff-86a6-4795-9ac2-0942e50b8191", + "id": "b5040d70-ee1e-40d4-80cb-0de97d55e600", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "type": "MTBDiagnosis" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "priority": { - "code": "3", - "display": "3", + "code": "4", + "display": "4", "system": "dnpm-dip/recommendation/priority" }, "levelOfEvidence": { "grading": { - "code": "m2B", - "display": "m2B", + "code": "undefined", + "display": "Nicht definiert", "system": "dnpm-dip/mtb/level-of-evidence/grading" }, "addendums": [ { - "code": "R", - "display": "R", + "code": "is", + "display": "is", "system": "dnpm-dip/mtb/level-of-evidence/addendum" } ], "publications": [ { - "id": "1386708679", + "id": "1998834209", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, "code": { - "code": "OP", - "display": "Operation", + "code": "WW", + "display": "Watchful Waiting", "system": "dnpm-dip/mtb/recommendation/procedure/category" }, "supportingVariants": [ { "variant": { - "id": "302808e8-25e5-44dd-bac1-1ec3bc901fca", + "id": "ed1be681-58f6-4dbc-84f1-ca5c85f6ef52", "type": "Variant" }, "gene": { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" } } @@ -2279,17 +3153,17 @@ ], "studyEnrollmentRecommendations": [ { - "id": "106ad35c-93c3-4c51-8da4-090489615969", + "id": "ab153511-2582-4a12-83c1-399cbf3ba9bf", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "type": "MTBDiagnosis" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "levelOfEvidence": { "grading": { "code": "m2C", @@ -2298,14 +3172,14 @@ }, "addendums": [ { - "code": "is", - "display": "is", + "code": "iv", + "display": "iv", "system": "dnpm-dip/mtb/level-of-evidence/addendum" } ], "publications": [ { - "id": "1525598879", + "id": "366546121", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } @@ -2318,20 +3192,20 @@ }, "study": [ { - "id": "NCT69553088", - "system": "NCT", + "id": "DRKS00036985", + "system": "DRKS", "type": "Study" } ], "supportingVariants": [ { "variant": { - "id": "4093aaf4-b5a9-4a36-a027-bf3b4a313a6f", + "id": "1553e32e-09e6-4f13-af10-379fef9531dc", "type": "Variant" }, "gene": { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" } } @@ -2340,30 +3214,30 @@ ], "histologyReevaluationRequests": [ { - "id": "b6fdf1d5-4434-47e7-97d8-3a085f772a07", + "id": "51800afe-63f1-44c6-aa93-62fafd9a1d7a", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "specimen": { - "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "id": "84aa1d75-0ba6-4266-b8e1-7a1337e44a3a", "type": "TumorSpecimen" }, - "issuedOn": "2025-07-09" + "issuedOn": "2025-12-10" } ], "rebiopsyRequests": [ { - "id": "5317db9f-af34-403f-8084-bed8d7822df7", + "id": "f7c6d328-8016-44a7-8205-f76e2d32efd3", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "tumorEntity": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", "type": "MTBDiagnosis" }, - "issuedOn": "2025-07-09" + "issuedOn": "2025-12-10" } ], "notes": [ @@ -2373,48 +3247,89 @@ ], "followUps": [ { - "date": "2009-08-12", + "date": "2006-12-22", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, - "lastContactDate": "2009-08-12" + "lastContactDate": "2006-12-22" } ], "claims": [ { - "id": "d9d6e12f-46a2-4fe0-8aa8-1839a6bf22cb", + "id": "6f4fbaa7-0b95-4d2a-be45-0086160adaad", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "recommendation": { - "id": "55f1bead-15c6-4fd5-8aa8-ee4c9b2cb285", + "id": "d1e90355-b1ba-46e1-a900-e439b63caea0", "type": "MTBMedicationRecommendation" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "stage": { - "code": "follow-up-claim", - "display": "Folgeantrag", + "code": "unknown", + "display": "Unbekannt", + "system": "dnpm-dip/mtb/claim/stage" + } + }, + { + "id": "265ce7ba-71ed-466d-91f2-d33525aa32f1", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "recommendation": { + "id": "c0687be9-6c5e-44f0-b083-688f2f4e9e07", + "type": "MTBMedicationRecommendation" + }, + "issuedOn": "2025-12-10", + "stage": { + "code": "revocation", + "display": "Widerspruch", "system": "dnpm-dip/mtb/claim/stage" } } ], "claimResponses": [ { - "id": "159caaab-9792-4004-993e-9c9410915a8a", + "id": "7cb3c600-4566-4a89-b461-c4114f7e442a", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "claim": { - "id": "d9d6e12f-46a2-4fe0-8aa8-1839a6bf22cb", + "id": "6f4fbaa7-0b95-4d2a-be45-0086160adaad", "type": "Claim" }, - "issuedOn": "2025-07-09", + "issuedOn": "2025-12-10", "status": { - "code": "unknown", - "display": "Unbekannt", + "code": "rejected", + "display": "Abgelehnt", + "system": "dnpm-dip/mtb/claim-response/status" + }, + "statusReason": [ + { + "code": "formal-reasons", + "display": "Inhaltliche Gründe", + "system": "dnpm-dip/mtb/claim-response/status-reason" + } + ] + }, + { + "id": "f61a9423-bb09-4bde-b86b-3b9a110127c9", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "claim": { + "id": "265ce7ba-71ed-466d-91f2-d33525aa32f1", + "type": "Claim" + }, + "issuedOn": "2025-12-10", + "status": { + "code": "accepted", + "display": "Angenommen", "system": "dnpm-dip/mtb/claim-response/status" } } @@ -2423,19 +3338,19 @@ { "history": [ { - "id": "f47600f1-9563-4964-b4db-1826faf01a52", + "id": "90e333f7-33d4-444b-9a66-33c85d1c9cee", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "reason": { - "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", - "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", "type": "MTBDiagnosis" }, "intent": { - "code": "K", - "display": "Kurativ", + "code": "P", + "display": "Palliativ", "system": "dnpm-dip/therapy/intent" }, "category": { @@ -2444,13 +3359,13 @@ "system": "dnpm-dip/therapy/category" }, "basedOn": { - "id": "55f1bead-15c6-4fd5-8aa8-ee4c9b2cb285", + "id": "d1e90355-b1ba-46e1-a900-e439b63caea0", "type": "MTBMedicationRecommendation" }, - "recordedOn": "2025-07-09", + "recordedOn": "2025-12-10", "status": { - "code": "on-going", - "display": "Laufend", + "code": "completed", + "display": "Abgeschlossen", "system": "dnpm-dip/therapy/status" }, "recommendationFulfillmentStatus": { @@ -2464,13 +3379,74 @@ "system": "dnpm-dip/therapy/dosage-density" }, "period": { - "start": "2009-04-29", - "end": "2009-10-21" + "start": "2006-10-13", + "end": "2007-01-26" + }, + "medication": [ + { + "code": "L01XX73", + "display": "Sotorasib", + "system": "http://fhir.de/CodeSystem/bfarm/atc", + "version": "2025" + } + ], + "notes": [ + "Notes on the therapy..." + ] + } + ] + }, + { + "history": [ + { + "id": "073cf464-76a8-4adc-931f-ff4006265033", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "reason": { + "id": "8aa2be4a-14a6-4dd3-9fad-0bb1362c92c2", + "display": "Bösartige Neubildung: Cervix uteri, mehrere Teilbereiche überlappend", + "type": "MTBDiagnosis" + }, + "intent": { + "code": "K", + "display": "Kurativ", + "system": "dnpm-dip/therapy/intent" + }, + "category": { + "code": "O", + "display": "Ohne Bezug zur operativen Therapie", + "system": "dnpm-dip/therapy/category" + }, + "basedOn": { + "id": "c0687be9-6c5e-44f0-b083-688f2f4e9e07", + "type": "MTBMedicationRecommendation" + }, + "recordedOn": "2025-12-10", + "status": { + "code": "completed", + "display": "Abgeschlossen", + "system": "dnpm-dip/therapy/status" + }, + "recommendationFulfillmentStatus": { + "code": "complete", + "display": "Komplett", + "system": "dnpm-dip/therapy/recommendation-fulfillment-status" + }, + "dosage": { + "code": "over-50%", + "display": ">= 50 %", + "system": "dnpm-dip/therapy/dosage-density" + }, + "period": { + "start": "2006-07-07", + "end": "2007-01-26" }, "medication": [ { - "code": "L01FX03", - "display": "Catumaxomab", + "code": "L01FX09", + "display": "Mogamulizumab", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -2484,26 +3460,48 @@ ], "responses": [ { - "id": "5da70b0a-e683-4de8-8671-b6508f237fc9", + "id": "78a86a87-0e21-4f1d-8d0d-c22f80e3de4c", "patient": { - "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", "type": "Patient" }, "therapy": { - "id": "f47600f1-9563-4964-b4db-1826faf01a52", + "id": "90e333f7-33d4-444b-9a66-33c85d1c9cee", "type": "MTBSystemicTherapy" }, - "effectiveDate": "2009-08-12", + "effectiveDate": "2006-12-22", "method": { "code": "RANO", "display": "Nach RANO-Kriterien", "system": "dnpm-dip/mtb/response/method" }, "value": { + "code": "PD", + "display": "Progressive Disease", + "system": "RECIST" + } + }, + { + "id": "3d13dde1-a171-444b-baee-3a225d1e5d36", + "patient": { + "id": "4ba7adb6-ee5a-40d5-89fe-670cb6af86c6", + "type": "Patient" + }, + "therapy": { + "id": "073cf464-76a8-4adc-931f-ff4006265033", + "type": "MTBSystemicTherapy" + }, + "effectiveDate": "2006-09-08", + "method": { + "code": "RECIST", + "display": "Nach RECIST-Kriterien", + "system": "dnpm-dip/mtb/response/method" + }, + "value": { "code": "SD", "display": "Stable Disease", "system": "RECIST" } } ] -} +}
\ No newline at end of file |