diff options
| author | Paul-Christian Volkmer | 2025-07-20 11:57:53 +0200 |
|---|---|---|
| committer | GitHub | 2025-07-20 11:57:53 +0200 |
| commit | 1a5737189c9e74fe0dc17fca3e88eb07cb6d467f (patch) | |
| tree | 41054ed46d5ce366f65ed4032856a43a3bfb91de /src | |
| parent | 7543785116a3d318f3abba604d2616a19e2037ce (diff) | |
chore: update mtb data model example file (#123)
Diffstat (limited to 'src')
| -rw-r--r-- | src/test/resources/mv64e-mtb-fake-patient.json | 1949 |
1 files changed, 915 insertions, 1034 deletions
diff --git a/src/test/resources/mv64e-mtb-fake-patient.json b/src/test/resources/mv64e-mtb-fake-patient.json index 291f22d..43fc2ef 100644 --- a/src/test/resources/mv64e-mtb-fake-patient.json +++ b/src/test/resources/mv64e-mtb-fake-patient.json @@ -1,12 +1,13 @@ { "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "gender": { - "code": "male", - "display": "Männlich", + "code": "female", + "display": "Weiblich", "system": "Gender" }, - "birthDate": "1961-09-01", + "birthDate": "1962-10-21", + "dateOfDeath": "2009-10-21", "healthInsurance": { "type": { "code": "GKV", @@ -24,28 +25,28 @@ "municipalityCode": "12345" }, "age": { - "value": 63, + "value": 47, "unit": "Years" }, "vitalStatus": { - "code": "alive", - "display": "Lebend", + "code": "deceased", + "display": "Verstorben", "system": "dnpm-dip/patient/vital-status" } }, "episodesOfCare": [ { - "id": "5481850f-f266-4d2f-8fbc-6bb790680d8f", + "id": "d8b68856-3ba2-4d43-9653-6924897f5eab", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "period": { - "start": "2024-12-24" + "start": "2025-01-09" }, "diagnoses": [ { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", "type": "MTBDiagnosis" } ] @@ -53,12 +54,12 @@ ], "diagnoses": [ { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "recordedOn": "2023-03-01", + "recordedOn": "2007-10-21", "type": { "history": [ { @@ -67,35 +68,35 @@ "display": "Hauptdiagnose", "system": "dnpm-dip/mtb/diagnosis/type" }, - "date": "2023-03-01" + "date": "2007-10-21" } ] }, "code": { - "code": "C50.1", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "code": "C72.5", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm", "version": "2025" }, "topography": { - "code": "C50.1", - "display": "Zentraler Drüsenkörper der Brust", + "code": "C72.5", + "display": "Hirnnerven o.n.A.", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "grading": { "history": [ { - "date": "2023-03-01", + "date": "2007-10-21", "codes": [ { - "code": "U", - "display": "U = unbekannt", + "code": "3", + "display": "3 = schlecht differenziert", "system": "https://www.basisdatensatz.de/feld/161/grading" }, { - "code": "2", - "display": "Diffuse astrocytoma", + "code": "3", + "display": "Anaplastic astrocytoma", "system": "dnpm-dip/mtb/who-grading-cns-tumors", "version": "2021" } @@ -106,7 +107,7 @@ "staging": { "history": [ { - "date": "2023-03-01", + "date": "2007-10-21", "method": { "code": "clinical", "display": "Klinisch", @@ -114,15 +115,15 @@ }, "tnmClassification": { "tumor": { - "code": "T1", + "code": "T0", "system": "UICC" }, "nodes": { - "code": "N2", + "code": "Nx", "system": "UICC" }, "metastasis": { - "code": "Mx", + "code": "M0", "system": "UICC" } }, @@ -137,8 +138,8 @@ ] }, "guidelineTreatmentStatus": { - "code": "unknown", - "display": "Unbekannt", + "code": "impossible", + "display": "Leitlinientherapie nicht möglich", "system": "dnpm-dip/mtb/diagnosis/guideline-treatment-status" }, "notes": [ @@ -148,42 +149,42 @@ ], "familyMemberHistories": [ { - "id": "f982b161-f8a3-4b5b-a390-1ef0d84efc1b", + "id": "0eac775e-ea13-49d4-a390-a5e99744ac6b", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "relationship": { - "code": "EXT", - "display": "Verwandter weiteren Grades", + "code": "FAMMEMB", + "display": "Verwandter ersten Grades", "system": "dnpm-dip/mtb/family-meber-history/relationship-type" } } ], "guidelineTherapies": [ { - "id": "0c696b1a-d123-419b-9a6f-e79322392f4e", + "id": "af77fcc8-bcdc-41fb-9989-c4ad2fd9ce3c", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "therapyLine": 3, + "therapyLine": 8, "intent": { "code": "X", "display": "Keine Angabe", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "I", - "display": "Intraopterativ", + "code": "A", + "display": "Adjuvant", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-06-24", + "recordedOn": "2025-07-09", "status": { "code": "stopped", "display": "Abgebrochen", @@ -195,13 +196,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2024-04-24", - "end": "2024-12-18" + "start": "2024-03-09", + "end": "2024-08-10" }, "medication": [ { - "code": "L01EX02", - "display": "Sorafenib", + "code": "L01XX58", + "display": "Epacadostat", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -211,28 +212,28 @@ ] }, { - "id": "da26f4c4-834e-4f6a-86eb-4df13c4a442f", + "id": "f922939a-926e-4319-90e7-488ed9027d6d", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "therapyLine": 4, + "therapyLine": 5, "intent": { "code": "X", "display": "Keine Angabe", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "A", - "display": "Adjuvant", + "code": "I", + "display": "Intraopterativ", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-06-24", + "recordedOn": "2025-07-09", "status": { "code": "stopped", "display": "Abgebrochen", @@ -244,13 +245,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2024-06-24", - "end": "2025-02-24" + "start": "2024-04-09", + "end": "2024-09-10" }, "medication": [ { - "code": "L01EX13", - "display": "Gilteritinib", + "code": "L01EG01", + "display": "Temsirolimus", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -262,80 +263,40 @@ ], "guidelineProcedures": [ { - "id": "09ac6bfb-05bb-4c8f-b65a-dae96407939c", + "id": "b6d5bd15-356d-468a-a816-5fd955fc51a2", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "therapyLine": 3, + "therapyLine": 2, "intent": { "code": "X", "display": "Keine Angabe", "system": "dnpm-dip/therapy/intent" }, "code": { - "code": "nuclear-medicine", - "display": "Nuklearmedizinische Therapie", - "system": "dnpm-dip/mtb/procedure/type" - }, - "status": { - "code": "stopped", - "display": "Abgebrochen", - "system": "dnpm-dip/therapy/status" - }, - "statusReason": { - "code": "patient-death", - "display": "Tod", - "system": "dnpm-dip/therapy/status-reason" - }, - "recordedOn": "2025-06-24", - "period": { - "start": "2024-12-24" - }, - "notes": [ - "Notes on the therapeutic procedure..." - ] - }, - { - "id": "1d12955f-216f-4731-8a37-e2eca4c2a735", - "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", - "type": "Patient" - }, - "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", - "type": "MTBDiagnosis" - }, - "therapyLine": 1, - "intent": { - "code": "S", - "display": "Sonstiges", - "system": "dnpm-dip/therapy/intent" - }, - "code": { - "code": "surgery", - "display": "OP", + "code": "radio-therapy", + "display": "Strahlen-Therapie", "system": "dnpm-dip/mtb/procedure/type" }, "status": { - "code": "completed", - "display": "Abgeschlossen", + "code": "on-going", + "display": "Laufend", "system": "dnpm-dip/therapy/status" }, "statusReason": { - "code": "progression", - "display": "Progression", + "code": "regular-completion-with-substance-change", + "display": "Reguläres Ende mit Substanzwechsel", "system": "dnpm-dip/therapy/status-reason" }, - "recordedOn": "2025-06-24", + "recordedOn": "2025-07-09", "period": { - "start": "2024-12-24" + "start": "2025-01-09" }, "notes": [ "Notes on the therapeutic procedure..." @@ -344,45 +305,45 @@ ], "performanceStatus": [ { - "id": "7cf3d19b-a537-47e4-b7f0-d324e8b1ad70", + "id": "279b4954-7901-4b0b-89f3-1f90b12bcc02", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "effectiveDate": "2025-06-24", + "effectiveDate": "2025-07-09", "value": { - "code": "1", - "display": "ECOG 1", + "code": "3", + "display": "ECOG 3", "system": "ECOG-Performance-Status" } } ], "specimens": [ { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "diagnosis": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", "type": "MTBDiagnosis" }, "type": { - "code": "unknown", - "display": "Unbekannt", + "code": "FFPE", + "display": "FFPE", "system": "dnpm-dip/mtb/tumor-specimen/type" }, "collection": { - "date": "2025-06-24", + "date": "2025-07-09", "method": { - "code": "unknown", - "display": "Unbekannt", + "code": "biopsy", + "display": "Biopsie", "system": "dnpm-dip/mtb/tumor-specimen/collection/method" }, "localization": { - "code": "unknown", - "display": "Unbekannt", + "code": "local-recurrence", + "display": "Lokalrezidiv", "system": "dnpm-dip/mtb/tumor-specimen/collection/localization" } } @@ -390,9 +351,9 @@ ], "priorDiagnosticReports": [ { - "id": "0209a1fa-3948-4bc5-a2f5-988818057544", + "id": "a7f20f97-c9ea-424d-add6-605dc2461782", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "performer": { @@ -400,9 +361,9 @@ "display": "Molekular-Pathologie UKx", "type": "Institute" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, "type": { @@ -417,43 +378,43 @@ ], "histologyReports": [ { - "id": "1c51bb6f-b551-43a4-9923-6db7fe36440c", + "id": "d57816b6-18b5-485d-9d7f-fc31004c429e", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "results": { "tumorMorphology": { - "id": "a177e88e-af76-45c8-ba93-e2f2339888a0", + "id": "21f1d157-6f40-4127-9b2f-91f32fedceb0", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, "value": { - "code": "9719/3", - "display": "Nasales NK/T-Zell-Lymphom", + "code": "9542/3", + "display": "Epitheloider maligner peripherer Nervenscheidentumor", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "note": "Notes..." }, "tumorCellContent": { - "id": "32605a2f-4c5c-4f5a-9909-326955405fe0", + "id": "81a42ef1-f9fe-4dfe-a876-cf1a262ca4ce", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, "method": { @@ -461,190 +422,134 @@ "display": "Histologisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - "value": 0.40875903241796807 + "value": 0.12624946426974026 } } } ], "ihcReports": [ { - "id": "ced8a836-262e-4067-b272-94c8f9222446", + "id": "2046a862-66e0-4402-bb93-b64ce179d014", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "results": { "proteinExpression": [ { - "id": "07bdd4f4-6df7-4c22-9ef2-2abb86cf4666", + "id": "15d628bb-6e6a-435f-98dd-8bbc2f0311d1", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "protein": { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, "value": { - "code": "not-exp", - "display": "Nicht exprimiert", + "code": "1+", + "display": "1+", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 21, + "tpsScore": 42, "icScore": { "code": "1", "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "6", - "display": ">= 75%", + "code": "4", + "display": ">= 25%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "38ac3c86-7d13-4d5d-a85d-7d79846aa85d", + "id": "a7af8f99-b917-4498-8c95-f09818906de2", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "protein": { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:391", + "display": "AKT1", "system": "https://www.genenames.org/" }, "value": { - "code": "3+", - "display": "3+", + "code": "1+", + "display": "1+", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 46, + "tpsScore": 90, "icScore": { "code": "0", "display": "< 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "1", - "display": ">= 1%", + "code": "4", + "display": ">= 25%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "002dd577-7a1e-4e47-ae63-bc84e641565e", + "id": "ea2d53e1-9a52-4fb2-87fd-b8b9acfb4017", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "protein": { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, "value": { - "code": "not-exp", - "display": "Nicht exprimiert", + "code": "1+", + "display": "1+", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 12, + "tpsScore": 41, "icScore": { "code": "0", "display": "< 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "1", - "display": ">= 1%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "70cfa37b-6a87-4108-a7ea-99c7c2f210dc", - "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", - "type": "Patient" - }, - "protein": { - "code": "HGNC:3690", - "display": "FGFR3", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "not-exp", - "display": "Nicht exprimiert", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 29, - "icScore": { - "code": "0", - "display": "< 1%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "1", - "display": ">= 1%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "cad30474-e6e2-4923-bd05-57bbce01708c", - "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", - "type": "Patient" - }, - "protein": { - "code": "HGNC:1753", - "display": "CDH13", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "unknown", - "display": "untersucht, kein Ergebnis", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 51, - "icScore": { "code": "2", "display": ">= 5%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "3", - "display": ">= 10%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "cf0ff1b1-e0db-48f3-aa07-684d626f939f", + "id": "b0794bbd-6e4e-442f-bfcf-cf2558ae3069", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "protein": { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" }, "value": { - "code": "not-exp", - "display": "Nicht exprimiert", + "code": "unknown", + "display": "untersucht, kein Ergebnis", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 81, + "tpsScore": 83, "icScore": { - "code": "2", - "display": ">= 5%", + "code": "1", + "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "2", - "display": ">= 5%", + "code": "5", + "display": ">= 50%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } } @@ -653,18 +558,42 @@ } } ], + "msiFindings": [ + { + "id": "73df8592-b79a-4277-ab5b-0d59c4af5659", + "patient": { + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "type": "Patient" + }, + "specimen": { + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", + "type": "TumorSpecimen" + }, + "method": { + "code": "PCR", + "display": "PCR", + "system": "dnpm-dip/mtb/msi/method" + }, + "value": 0.800039814642262, + "interpretation": { + "code": "msi-high", + "display": "MSI high", + "system": "dnpm-dip/mtb/msi/interpretation" + } + } + ], "ngsReports": [ { - "id": "3788004a-2c21-4dfb-92d8-70d1b31e39d7", + "id": "76003d5a-8c9e-4587-8e39-d4c785d234ea", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "type": { "code": "genome-long-read", "display": "Genome long-read", @@ -675,19 +604,19 @@ "kitType": "Kit Type", "kitManufacturer": "Manufacturer", "sequencer": "Sequencer", - "referenceGenome": "HG19", + "referenceGenome": "GRCh37", "pipeline": "https://github.com/pipeline-project" } ], "results": { "tumorCellContent": { - "id": "26a6f41e-c2a4-4a28-ba62-95453c880579", + "id": "a76fbe2c-7e89-4abe-af89-884d03fec74e", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, "method": { @@ -695,36 +624,36 @@ "display": "Bioinformatisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - 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"chromosome": "chr20", + "chromosome": "chr19", "localization": [ { - "code": "intronic", - "display": "Intronic", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 47283, - "end": 47325 + "start": 784, + "end": 826 }, "endRange": { - "start": 47554, - "end": 47604 + "start": 1163, + "end": 1213 }, - "totalCopyNumber": 3, - "relativeCopyNumber": 0.5183732460975659, - "cnA": 0.4575487225914149, - "cnB": 0.2296504258992984, + "totalCopyNumber": 7, + "relativeCopyNumber": 0.5881569243593987, + "cnA": 0.8272442044751694, + "cnB": 0.07961294501228111, "reportedAffectedGenes": [ { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:25829", + "display": "ABRAXAS1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1777", - "display": "CDK6", + "code": "HGNC:6973", + "display": "MDM2", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:25662", + "display": "AAGAB", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:391", + "display": "AKT1", "system": "https://www.genenames.org/" }, { "code": "HGNC:76", "display": "ABL1", "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:886", + "display": "ATRX", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1777", + "display": "CDK6", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1753", + "display": "CDH13", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3690", + "display": "FGFR3", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:9967", + "display": "RET", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", + "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", "type": { - "code": "low-level-gain", - "display": "Low-level-gain", + "code": "high-level-gain", + "display": "High-level-gain", "system": "dnpm-dip/mtb/ngs-report/cnv/type" }, "copyNumberNeutralLoH": [ { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:6973", + "display": "MDM2", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:1100", + "display": "BRCA1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:886", + "display": "ATRX", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:9967", + "display": "RET", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3942", + "display": "MTOR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3236", + "display": "EGFR", "system": "https://www.genenames.org/" } ] }, { - "id": "da5cc035-4c3a-4178-b8f1-9beb10e26bfa", + "id": "9ca350f8-7def-4a6b-9251-d76cda6c9066", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "chromosome": "chr12", + "chromosome": "chr7", "localization": [ { - "code": "coding-region", - "display": "Coding region", + "code": "intronic", + "display": "Intronic", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 47366, - "end": 47408 + "start": 33756, + "end": 33798 }, "endRange": { - "start": 47422, - "end": 47472 + "start": 33971, + "end": 34021 }, "totalCopyNumber": 5, - "relativeCopyNumber": 0.042907471951150966, - "cnA": 0.7031003234003745, - "cnB": 0.45868310119316547, + "relativeCopyNumber": 0.9849081436334101, + "cnA": 0.7654754033556277, + "cnB": 0.4113320623943184, "reportedAffectedGenes": [ { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:25829", + "display": "ABRAXAS1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:76", + "display": "ABL1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, { @@ -1226,8 +1098,13 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3942", + "display": "MTOR", "system": "https://www.genenames.org/" } ], @@ -1239,68 +1116,68 @@ }, "copyNumberNeutralLoH": [ { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:3942", + "display": "MTOR", "system": "https://www.genenames.org/" }, { - "code": "HGNC:21597", - "display": "ACAD10", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:25662", + "display": "AAGAB", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" } ] }, { - "id": "6d8cfac1-7809-46c3-afcb-cf663de78f7f", + "id": "3f0d9d82-46ad-44e9-85a4-fc5fccf78dae", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "chromosome": "chr2", + "chromosome": "chr7", "localization": [ { - "code": "intergenic", - "display": "Intergenic", + "code": "splicing-region", + "display": "splicing region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 21639, - "end": 21681 + "start": 5174, + "end": 5216 }, "endRange": { - "start": 22558, - "end": 22608 + "start": 5568, + "end": 5618 }, "totalCopyNumber": 4, - "relativeCopyNumber": 0.0963886754685026, - "cnA": 0.7203179871076737, - "cnB": 0.34976893933294917, + "relativeCopyNumber": 0.7837528048147511, + "cnA": 0.8598945814656759, + "cnB": 0.45985813940248477, "reportedAffectedGenes": [ { "code": "HGNC:33", @@ -1308,28 +1185,18 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:25829", - "display": "ABRAXAS1", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3690", - "display": "FGFR3", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:25662", + "display": "AAGAB", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1777", - "display": "CDK6", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, { @@ -1338,29 +1205,14 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:3689", - "display": "FGFR2", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:34", + "display": "ABCA4", "system": "https://www.genenames.org/" }, { "code": "HGNC:3236", "display": "EGFR", "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:18615", - "display": "BRAFP1", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:6407", - "display": "KRAS", - "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", @@ -1371,65 +1223,80 @@ }, "copyNumberNeutralLoH": [ { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:76", + "display": "ABL1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "HGNC:1777", + "display": "CDK6", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" } ] }, { - "id": "79b1b2f1-eece-469a-bf9d-d742ace3b4f5", + "id": "67beb706-0870-470e-b6c1-bf28662a60f6", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "chromosome": "chr4", + "chromosome": "chr21", "localization": [ { - "code": "splicing-region", - "display": "splicing region", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 10032, - "end": 10074 + "start": 46825, + "end": 46867 }, "endRange": { - "start": 10429, - "end": 10479 + "start": 47805, + "end": 47855 }, - "totalCopyNumber": 2, - "relativeCopyNumber": 0.43102997556480316, - "cnA": 0.0626602855041446, - "cnB": 0.9272306017862723, + "totalCopyNumber": 4, + "relativeCopyNumber": 0.667919646926896, + "cnA": 0.6344586287700189, + "cnB": 0.5935064515068115, "reportedAffectedGenes": [ { + "code": "HGNC:6973", + "display": "MDM2", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:3690", "display": "FGFR3", "system": "https://www.genenames.org/" @@ -1440,41 +1307,51 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:3236", + "display": "EGFR", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:25662", + "display": "AAGAB", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:9967", + "display": "RET", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", "type": { - "code": "low-level-gain", - "display": "Low-level-gain", + "code": "high-level-gain", + "display": "High-level-gain", "system": "dnpm-dip/mtb/ngs-report/cnv/type" }, "copyNumberNeutralLoH": [ { - "code": "HGNC:11998", - "display": "TP53", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { @@ -1488,43 +1365,48 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:3236", + "display": "EGFR", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" } ] }, { - "id": "7ef061c2-25d3-4ab1-b3b5-415711e74763", + "id": "302808e8-25e5-44dd-bac1-1ec3bc901fca", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "chromosome": "chr1", + "chromosome": "chr15", "localization": [ { - "code": "intronic", - "display": "Intronic", + "code": "splicing-region", + "display": "splicing region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 21367, - "end": 21409 + "start": 29564, + "end": 29606 }, "endRange": { - "start": 22243, - "end": 22293 + "start": 30496, + "end": 30546 }, "totalCopyNumber": 6, - "relativeCopyNumber": 0.5325580143964234, - "cnA": 0.001090613467988999, - "cnB": 0.796867620835479, + "relativeCopyNumber": 0.9554782410556386, + "cnA": 0.14914124694657616, + "cnB": 0.04403923699882417, "reportedAffectedGenes": [ { "code": "HGNC:11998", @@ -1532,18 +1414,43 @@ "system": "https://www.genenames.org/" }, { + "code": "HGNC:5173", + "display": "HRAS", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:25829", "display": "ABRAXAS1", "system": "https://www.genenames.org/" }, { + "code": "HGNC:3690", + "display": "FGFR3", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:391", + "display": "AKT1", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:76", "display": "ABL1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:886", + "display": "ATRX", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21597", + "display": "ACAD10", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:18615", + "display": "BRAFP1", "system": "https://www.genenames.org/" }, { @@ -1552,18 +1459,23 @@ "system": "https://www.genenames.org/" }, { + "code": "HGNC:25662", + "display": "AAGAB", + "system": "https://www.genenames.org/" + }, + { "code": "HGNC:1100", "display": "BRCA1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" } ], @@ -1575,8 +1487,8 @@ }, "copyNumberNeutralLoH": [ { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { @@ -1585,18 +1497,18 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, { @@ -1605,43 +1517,48 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:18615", + "display": "BRAFP1", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" } ] }, { - "id": "b6c87ffe-cafa-4017-8304-cc7d5e5ed6ef", + "id": "251c4538-efd4-41cb-ac11-7aa6004b4546", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "chromosome": "chr4", + "chromosome": "chr6", "localization": [ { - "code": "intergenic", - "display": "Intergenic", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 28913, - "end": 28955 + "start": 10903, + "end": 10945 }, "endRange": { - "start": 29073, - "end": 29123 + "start": 11359, + "end": 11409 }, - "totalCopyNumber": 5, - "relativeCopyNumber": 0.24079048197395347, - "cnA": 0.8864208860638342, - "cnB": 0.9335254612742215, + "totalCopyNumber": 7, + "relativeCopyNumber": 0.3329690143900391, + "cnA": 0.6937471513244393, + "cnB": 0.07580581478248649, "reportedAffectedGenes": [ { "code": "HGNC:11998", @@ -1649,13 +1566,13 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:1100", + "display": "BRCA1", "system": "https://www.genenames.org/" }, { @@ -1664,21 +1581,6 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3689", - "display": "FGFR2", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:34", - "display": "ABCA4", - "system": "https://www.genenames.org/" - }, - { "code": "HGNC:3942", "display": "MTOR", "system": "https://www.genenames.org/" @@ -1687,11 +1589,6 @@ "code": "HGNC:18615", "display": "BRAFP1", "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:6407", - "display": "KRAS", - "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", @@ -1702,13 +1599,13 @@ }, "copyNumberNeutralLoH": [ { - "code": "HGNC:33", - "display": "ABCA3", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:5173", + "display": "HRAS", "system": "https://www.genenames.org/" }, { @@ -1717,28 +1614,33 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" } ] @@ -1746,75 +1648,75 @@ ], "dnaFusions": [ { - "id": "80439a87-61a6-449f-ab0e-ea207336b650", + "id": "1175b70b-b667-47b2-831d-c8537f035b47", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "localization": [ { - "code": "splicing-region", - "display": "splicing region", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "chromosome": "chr10", + "chromosome": "chr19", "gene": { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" }, - "position": 988 + "position": 640 }, "fusionPartner3prime": { - "chromosome": "chr19", + "chromosome": "chr7", "gene": { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" }, - "position": 337 + "position": 214 }, - "reportedNumReads": 7 + "reportedNumReads": 8 }, { - "id": "9d1e2965-d90a-40f1-b40f-c73de15980cf", + "id": "1554981f-5fb8-4af4-9469-9577039873a2", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "localization": [ { - "code": "regulatory-region", - "display": "Regulatory region", + "code": "splicing-region", + "display": "splicing region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "chromosome": "chr3", + "chromosome": "chr17", "gene": { - "code": "HGNC:6973", - "display": "MDM2", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, - "position": 61 + "position": 361 }, "fusionPartner3prime": { - "chromosome": "chrX", + "chromosome": "chr15", "gene": { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:391", + "display": "AKT1", "system": "https://www.genenames.org/" }, - "position": 728 + "position": 522 }, - "reportedNumReads": 5 + "reportedNumReads": 9 }, { - "id": "16efbf55-955f-4044-94db-905b74c67d6e", + "id": "8acbfaea-f14a-4acc-bf2b-c704d5389528", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "localization": [ @@ -1825,72 +1727,97 @@ } ], "fusionPartner5prime": { - "chromosome": "chr3", + "chromosome": "chr20", "gene": { - "code": "HGNC:391", - "display": "AKT1", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, - "position": 307 + "position": 545 }, "fusionPartner3prime": { "chromosome": "chr22", "gene": { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:21597", + "display": "ACAD10", "system": "https://www.genenames.org/" }, - "position": 297 + "position": 360 }, - "reportedNumReads": 3 + "reportedNumReads": 4 }, { - "id": "b184adc5-50e4-4a48-8fc4-16442eadec78", + "id": "1b64154c-4998-4863-be54-015dbc4e15b1", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "localization": [ { - "code": "splicing-region", - "display": "splicing region", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "chromosome": "chr21", + "chromosome": "chr1", "gene": { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, - "position": 732 + "position": 564 }, "fusionPartner3prime": { - "chromosome": "chr14", + "chromosome": "chr1", "gene": { - "code": "HGNC:3689", - "display": "FGFR2", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, - "position": 72 + "position": 985 }, - "reportedNumReads": 5 - } - ], - "rnaFusions": [ + "reportedNumReads": 4 + }, { - "id": "2d813e27-e662-46b6-8bfa-62473c591a68", + "id": "a285967c-192c-4716-ae4c-db0fac6d8aa0", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "externalIds": [ + "localization": [ { - "value": "8560bec8-434c-485a-9dcf-357903a668df", - "system": "https://cancer.sanger.ac.uk/cosmic" + "code": "splicing-region", + "display": "splicing region", + "system": "dnpm-dip/variant/localization" } ], + "fusionPartner5prime": { + "chromosome": "chr21", + "gene": { + "code": "HGNC:21597", + "display": "ACAD10", + "system": "https://www.genenames.org/" + }, + "position": 155 + }, + "fusionPartner3prime": { + "chromosome": "chr11", + "gene": { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + "position": 115 + }, + "reportedNumReads": 3 + }, + { + "id": "1fb9a606-b876-4c54-b125-6b299b2fdc8d", + "patient": { + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", + "type": "Patient" + }, "localization": [ { "code": "intergenic", @@ -1899,98 +1826,64 @@ } ], "fusionPartner5prime": { - 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"externalIds": [ - { - "value": "32d72312-10c9-42ee-be8b-2e84a91750eb", - "system": "https://cancer.sanger.ac.uk/cosmic" - } - ], "localization": [ { - "code": "intronic", - "display": "Intronic", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "transcriptId": { - "value": "82fce546-f37e-4091-b403-68a6c1331f32", - "system": "https://www.ensembl.org" - }, - "exonId": "8", + "chromosome": "chr4", "gene": { - "code": "HGNC:1097", - "display": "BRAF", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, - "position": 215, - "strand": "-" + "position": 219 }, "fusionPartner3prime": { - "transcriptId": { - "value": "74784723-528c-463b-965a-7b935ef6b892", - "system": "https://www.ensembl.org" - }, - "exonId": "2", + "chromosome": "chr18", "gene": { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, - "position": 694, - "strand": "-" + "position": 955 }, - "effect": "Effect", "reportedNumReads": 8 }, { - "id": "139e3749-4ce8-4add-aff8-d50edb63a910", + "id": "794aec2c-de1b-406c-94e0-e8248d5885d4", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "externalIds": [ - { - "value": "ae45ead3-0e7e-4e7f-9471-80c814cb931b", - "system": "https://cancer.sanger.ac.uk/cosmic" - } - ], "localization": [ { "code": "coding-region", @@ -1999,235 +1892,226 @@ } ], "fusionPartner5prime": { - "transcriptId": { - "value": "aed32d17-6067-4781-9483-cb0c01a8c183", - "system": "https://www.ncbi.nlm.nih.gov/refseq" - }, - "exonId": "3", + "chromosome": "chr18", "gene": { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:391", + "display": "AKT1", "system": "https://www.genenames.org/" }, - "position": 122, - "strand": "-" + "position": 914 }, "fusionPartner3prime": { - "transcriptId": { - "value": "8f459b0b-86b8-431c-9d86-f2454e2806c6", - "system": "https://www.ensembl.org" - }, - "exonId": "11", + "chromosome": "chr15", "gene": { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, - "position": 119, - "strand": "+" + "position": 299 }, - "effect": "Effect", "reportedNumReads": 8 - }, + } + ], + "rnaFusions": [ { - "id": "8e6479b8-5870-42a0-8fa2-be8c33e9c19b", + "id": "0c6512d1-d5c5-4600-8fe6-c0453d56c5fd", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "externalIds": [ { - "value": "d40f6710-9923-4e03-8675-46ea7ebc185a", + "value": "6dfcb9e2-e714-4fbc-ad4e-8fa2bea1a79f", "system": "https://cancer.sanger.ac.uk/cosmic" } ], "localization": [ { - "code": "intergenic", - "display": "Intergenic", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { "transcriptId": { - "value": "958a73f6-3bb0-4491-b916-58cd5a968f35", + "value": "ba78ec95-f31b-42b6-90d0-61161cad9b01", "system": "https://www.ncbi.nlm.nih.gov/refseq" }, - 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"code": "splicing-region", - "display": "splicing region", + "code": "intergenic", + "display": "Intergenic", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { "transcriptId": { - "value": "04f2a51a-d782-42d2-a313-67e2ea362155", + "value": "7185fa47-ca77-4ffb-b7d4-96e0929c8beb", "system": "https://www.ncbi.nlm.nih.gov/refseq" }, - "exonId": "9", + "exonId": "2", "gene": { - "code": "HGNC:21597", - "display": "ACAD10", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, - "position": 575, + "position": 942, "strand": "-" }, "fusionPartner3prime": { "transcriptId": { - "value": "56e704c3-b889-4768-b33a-f0be5cc3ea4d", + "value": "c0bf67cd-f0ee-4ce6-b3d9-b9ced8174db4", "system": "https://www.ncbi.nlm.nih.gov/refseq" }, - "exonId": "6", + "exonId": "9", "gene": { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" }, - "position": 537, + "position": 434, "strand": "-" }, "effect": "Effect", - "reportedNumReads": 8 + "reportedNumReads": 9 } ], "rnaSeqs": [] @@ -2236,96 +2120,98 @@ ], "carePlans": [ { - "id": "75f515ff-44e9-44ef-8de4-20750f160322", + "id": "785d0496-4e74-492e-b8cf-73390b0f4954", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "geneticCounselingRecommendation": { - "id": "708baa95-c6de-4e1d-9e2c-f40dd1d14a32", + "id": "23452d54-dfa9-48f7-a191-7df1b94594c2", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "reason": { - "code": "self-anamnesis", - "display": "Eigenanamnese", + "code": "secondary-tumor", + "display": "Zweittumor", "system": "dnpm-dip/mtb/recommendation/genetic-counseling/reason" } }, "medicationRecommendations": [ { - "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9", + "id": "55f1bead-15c6-4fd5-8aa8-ee4c9b2cb285", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "priority": { - "code": "4", - "display": "4", + "code": "3", + "display": "3", "system": "dnpm-dip/recommendation/priority" }, "levelOfEvidence": { "grading": { - "code": "m2B", - "display": "m2B", + "code": "m2C", + "display": "m2C", "system": "dnpm-dip/mtb/level-of-evidence/grading" }, "addendums": [ { - "code": "R", - "display": "R", + "code": "is", + "display": "is", "system": "dnpm-dip/mtb/level-of-evidence/addendum" } ], "publications": [ { - "id": "1802087682", + "id": "1525598879", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, - "category": { - "code": "SO", - "display": "Sonstiges", - "system": "dnpm-dip/mtb/recommendation/systemic-therapy/category" - }, + "category": [ + { + "code": "IM", + "display": "Immun-/Antikörpertherapie", + "system": "dnpm-dip/mtb/recommendation/systemic-therapy/category" + } + ], "medication": [ { - "code": "L01XX77", - "display": "Adagrasib", + "code": "L01FX03", + "display": "Catumaxomab", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } ], "useType": { - "code": "sec-preventive", - "display": "Sec-preventive", + "code": "compassionate", + "display": "Compassionate Use", "system": "dnpm-dip/mtb/recommendation/systemic-therapy/use-type" }, "supportingVariants": [ { "variant": { - "id": "a9487572-a2a5-4074-ba8b-1e73cf92b378", + "id": "4093aaf4-b5a9-4a36-a027-bf3b4a313a6f", "type": "Variant" }, "gene": { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" } } @@ -2334,26 +2220,26 @@ ], "procedureRecommendations": [ { - "id": "1f5aebc0-2f32-4fdf-96e3-ba2309a580e3", + "id": "57720dff-86a6-4795-9ac2-0942e50b8191", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "priority": { - "code": "2", - "display": "2", + "code": "3", + "display": "3", "system": "dnpm-dip/recommendation/priority" }, "levelOfEvidence": { "grading": { - "code": "undefined", - "display": "Nicht definiert", + "code": "m2B", + "display": "m2B", "system": "dnpm-dip/mtb/level-of-evidence/grading" }, "addendums": [ @@ -2365,26 +2251,26 @@ ], "publications": [ { - "id": "519591396", + "id": "1386708679", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, "code": { - "code": "AS", - "display": "Active Surveillance", + "code": "OP", + "display": "Operation", "system": "dnpm-dip/mtb/recommendation/procedure/category" }, "supportingVariants": [ { "variant": { - "id": "828dfee4-37e4-485a-8c6f-49f863903f3f", + "id": "302808e8-25e5-44dd-bac1-1ec3bc901fca", "type": "Variant" }, "gene": { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" } } @@ -2393,59 +2279,59 @@ ], "studyEnrollmentRecommendations": [ { - "id": "590cd85f-24b9-435c-bb63-8a719dfa7c8e", + "id": "106ad35c-93c3-4c51-8da4-090489615969", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "levelOfEvidence": { "grading": { - "code": "m2B", - "display": "m2B", + "code": "m2C", + "display": "m2C", "system": "dnpm-dip/mtb/level-of-evidence/grading" }, "addendums": [ { - "code": "R", - "display": "R", + "code": "is", + "display": "is", "system": "dnpm-dip/mtb/level-of-evidence/addendum" } ], "publications": [ { - "id": "1802087682", + "id": "1525598879", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, "priority": { - "code": "1", - "display": "1", + "code": "3", + "display": "3", "system": "dnpm-dip/recommendation/priority" }, "study": [ { - "id": "0509-104679-07-52", - "system": "Eudra-CT", + "id": "NCT69553088", + "system": "NCT", "type": "Study" } ], "supportingVariants": [ { "variant": { - "id": "a9487572-a2a5-4074-ba8b-1e73cf92b378", + "id": "4093aaf4-b5a9-4a36-a027-bf3b4a313a6f", "type": "Variant" }, "gene": { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" } } @@ -2454,30 +2340,30 @@ ], "histologyReevaluationRequests": [ { - "id": "38f2133a-f1cf-4af6-b441-c21953e43ed3", + "id": "b6fdf1d5-4434-47e7-97d8-3a085f772a07", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "specimen": { - "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", + "id": "c479b60d-c3e4-44d4-b0e5-c5891dd460ed", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-24" + "issuedOn": "2025-07-09" } ], "rebiopsyRequests": [ { - "id": "0860944d-ede1-453b-b7ea-b13ea0fb1d2f", + "id": "5317db9f-af34-403f-8084-bed8d7822df7", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "tumorEntity": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-24" + "issuedOn": "2025-07-09" } ], "notes": [ @@ -2487,48 +2373,48 @@ ], "followUps": [ { - "date": "2025-06-03", + "date": "2009-08-12", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, - "lastContactDate": "2025-06-03" + "lastContactDate": "2009-08-12" } ], "claims": [ { - "id": "5ec237d4-4857-475a-9931-0aa374a93634", + "id": "d9d6e12f-46a2-4fe0-8aa8-1839a6bf22cb", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "recommendation": { - "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9", + "id": "55f1bead-15c6-4fd5-8aa8-ee4c9b2cb285", "type": "MTBMedicationRecommendation" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "stage": { - "code": "unknown", - "display": "Unbekannt", + "code": "follow-up-claim", + "display": "Folgeantrag", "system": "dnpm-dip/mtb/claim/stage" } } ], "claimResponses": [ { - "id": "fed8817e-708a-4230-a7e1-95594b67e5ce", + "id": "159caaab-9792-4004-993e-9c9410915a8a", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "claim": { - "id": "5ec237d4-4857-475a-9931-0aa374a93634", + "id": "d9d6e12f-46a2-4fe0-8aa8-1839a6bf22cb", "type": "Claim" }, - "issuedOn": "2025-06-24", + "issuedOn": "2025-07-09", "status": { - "code": "accepted", - "display": "Angenommen", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/claim-response/status" } } @@ -2537,59 +2423,54 @@ { "history": [ { - "id": "0b2347b7-3b85-442d-aa46-e9c5c9ee7802", + "id": "f47600f1-9563-4964-b4db-1826faf01a52", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "reason": { - "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", - "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "id": "19de7fac-c8db-4936-b8fe-c47acda6599b", + "display": "Bösartige Neubildung: Sonstige und nicht näher bezeichnete Hirnnerven", "type": "MTBDiagnosis" }, "intent": { - "code": "P", - "display": "Palliativ", + "code": "K", + "display": "Kurativ", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "S", - "display": "Sonstiges", + "code": "N", + "display": "Neoadjuvant", "system": "dnpm-dip/therapy/category" }, "basedOn": { - "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9", + "id": "55f1bead-15c6-4fd5-8aa8-ee4c9b2cb285", "type": "MTBMedicationRecommendation" }, - "recordedOn": "2025-06-24", + "recordedOn": "2025-07-09", "status": { - "code": "stopped", - "display": "Abgebrochen", + "code": "on-going", + "display": "Laufend", "system": "dnpm-dip/therapy/status" }, - "statusReason": { - "code": "progression", - "display": "Progression", - "system": "dnpm-dip/therapy/status-reason" - }, "recommendationFulfillmentStatus": { "code": "partial", "display": "Partiell", "system": "dnpm-dip/therapy/recommendation-fulfillment-status" }, "dosage": { - "code": "under-50%", - "display": "< 50 %", + "code": "over-50%", + "display": ">= 50 %", "system": "dnpm-dip/therapy/dosage-density" }, "period": { - "start": "2025-03-18", - "end": "2025-06-24" + "start": "2009-04-29", + "end": "2009-10-21" }, "medication": [ { - "code": "L01XX77", - "display": "Adagrasib", + "code": "L01FX03", + "display": "Catumaxomab", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -2603,16 +2484,16 @@ ], "responses": [ { - "id": "70c6b774-ca26-4837-b424-5fc37e9a1548", + "id": "5da70b0a-e683-4de8-8671-b6508f237fc9", "patient": { - "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "id": "fae56ea7-24a7-4556-82fb-2b5dde71bb4d", "type": "Patient" }, "therapy": { - "id": "0b2347b7-3b85-442d-aa46-e9c5c9ee7802", + "id": "f47600f1-9563-4964-b4db-1826faf01a52", "type": "MTBSystemicTherapy" }, - "effectiveDate": "2025-06-03", + "effectiveDate": "2009-08-12", "method": { "code": "RANO", "display": "Nach RANO-Kriterien", |